Clinicopathologic Significance of HIF-1𝛼, CXCR4, and VEGF Expression in Colon Cancer

Table 2

Correlation of combined high expression of HIF-1α, CXCR4, and VEGF with lymph node status and distant metastasis.

	Lymph node metastasis		𝑃 value	Distant metastasis		𝑃-value
	Negative	Positive		Negative	Positive
HIF-1𝛼/CXCR4
(1) Both HIF-1𝛼/CXCR4 low expression	16 (89)	2 (11)	𝑃<.001	18 (100)	0 (0)	𝑃=.029
(2) One of HIF-1𝛼/CXCR4 high expression	13 (57)	10 (43)	(2) versus (3)	22 (96)	1 (4)	(2) versus (3)
(3) Both HIF-1𝛼/CXCR4 high expression	7 (26)	20 (74)	𝑃=.028	21 (78)	6 (22)	𝑃=.069
HIF-1𝛼/VEGF
(1) Both HIF-1𝛼/VEGF low expression	16 (84)	3 (16 )	𝑃<.001	19 (100)	0 (0)	𝑃=.021
(2) One of HIF-1𝛼/VEGF high expression	14 (61)	9 (39)	(2) versus (3)	22 (96)	1 (4)	(2) versus (3)
(3) Both HIF-1𝛼/VEGF high expression	6 (23)	20 (77)	𝑃=.007	20 (77)	6 (23)	𝑃=.062
CXCR4/VEGF
(1) Both CXCR4/VEGF low expression	15 (94)	1 (6)	𝑃<.001	16 (100)	0 (0)	𝑃=.012
(2)  One of CXCR4/VEGF high expression	13 (65)	7 (35)	(2) versus (3)	100)	0 (0)	(2) versus (3)
(3) Both CXCR4/VEGF high expression	8 (25)	24 (75)	𝑃=.004	25 (78)	7 (22)	𝑃=.035
HIF-1𝛼/CXCR4/VEGF
(1) Fewer than HIF-1𝛼, CXCR4, and VEGF high expression	31 (69)	14 (31)	𝑃<.001	44 (98)	1 (2)	𝑃<.001
(2) All of HIF-1𝛼, CXCR4, and VEGF high expression	5 (22)	18 (78)		17 (74)	6 (26)