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Clinical and Developmental Immunology
Volume 2010 (2010), Article ID 618517, 7 pages
Research Article

Atopic Dermatitis-Like Skin Lesions Reduced by Topical Application and Intraperitoneal Injection of Hirsutenone in NC/Nga Mice

1Department of Dermatology, College of Medicine, Chung-Ang University, Seoul 156-756, Republic of Korea
2College of Pharmacy, Chung-Ang University, Seoul 156-756, Republic of Korea
3Division of Marine Molecular Biotechnology, Gangneung-Wonju National University, 120 Gangneung Daehangno, Gangneung, Gangwon 210-702, Republic of Korea

Received 3 June 2010; Revised 5 October 2010; Accepted 15 October 2010

Academic Editor: Kurt Blaser

Copyright © 2010 Mi Sook Jeong et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Atopic dermatitis (AD) is a common inflammatory skin disease. The increasing prevalence and severity of AD have prompted the developments of safer, more effective drugs. Although topical corticosteroids have been used as first line therapy for AD, their potential side effects limit their clinical applications. To investigate the effect of hirsutenone (HIR), a diarylheptanoid compound, on AD-like skin lesions and other factors related to immune response is the aim of this paper Th2-related cytokines (IL-4, IL-5, IL-13), eosinophil, IgE inflammatory factors (COX-2, iNOS) levels were reduced in blood, lymphocytes, and tissue after HIR treatment. These results suggest that HIR might be an effective treatment for AD.