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Clinical and Developmental Immunology
Volume 2010 (2010), Article ID 618517, 7 pages
http://dx.doi.org/10.1155/2010/618517
Research Article

Atopic Dermatitis-Like Skin Lesions Reduced by Topical Application and Intraperitoneal Injection of Hirsutenone in NC/Nga Mice

1Department of Dermatology, College of Medicine, Chung-Ang University, Seoul 156-756, Republic of Korea
2College of Pharmacy, Chung-Ang University, Seoul 156-756, Republic of Korea
3Division of Marine Molecular Biotechnology, Gangneung-Wonju National University, 120 Gangneung Daehangno, Gangneung, Gangwon 210-702, Republic of Korea

Received 3 June 2010; Revised 5 October 2010; Accepted 15 October 2010

Academic Editor: Kurt Blaser

Copyright © 2010 Mi Sook Jeong et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. D. Simon, L. R. Braathen, and H.-U. Simon, “Eosinophils and atopic dermatitis,” Allergy, vol. 59, no. 6, pp. 561–570, 2004. View at Publisher · View at Google Scholar · View at Scopus
  2. C. A. Akdis, M. Akdis, A. Trautmann, and K. Blaser, “Immune regulation in atopic dermatitis,” Current Opinion in Immunology, vol. 12, no. 6, pp. 641–646, 2000. View at Publisher · View at Google Scholar · View at Scopus
  3. D. Thaçi, “Long term management of childhood atopic dermatitis with calcineurin inhibitors,” Hautarzt, vol. 54, no. 5, pp. 418–423, 2003. View at Google Scholar · View at Scopus
  4. Y. Asakawa, “Chemical constituents of Alnus firma (BETULACEAE). I. Phenyl propane derivatives isolated from Alnus firma,” Bulletin of the Chemical Society of Japan, vol. 43, no. 7, pp. 2223–2229, 1970. View at Google Scholar
  5. S.-J. Lee, Korea Folk Medicine, Seoul National University Publishing Center Press, Seoul, Republic of Korea, 1966.
  6. Y.-A. Lee, D.-W. Jeong, K.-H. Kim et al., “Antioxidant activity of diarylheptanoids from the leaves of Alnus hirsute,” Yakhak Hoeji, vol. 47, pp. 193–196, 2000. View at Google Scholar
  7. M. Kuroyanagi, M. Shimomae, Y. Nagashima et al., “New diarylheptanoids from Alnus japonica and their antioxidative activity,” Chemical and Pharmaceutical Bulletin, vol. 53, no. 12, pp. 1519–1523, 2005. View at Google Scholar · View at Scopus
  8. M.-W. Lee, N.-Y. Kim, M.-S. Park et al., “Diarylheptanoids with in vitro inducible nitric oxide synthesis inhibitory activity from Alnus hirsuta,” Planta Medica, vol. 66, no. 6, pp. 551–553, 2000. View at Publisher · View at Google Scholar · View at Scopus
  9. M.-W. Lee, J.-H. Kim, D.-W. Jeong, K.-H. Ahn, S.-H. Toh, and Y.-J. Surh, “Inhibition of cyclooxygenase-2 expression by diarylheptanoids from the bark of Alnus hirsuta var. sibirica,” Biological and Pharmaceutical Bulletin, vol. 23, no. 4, pp. 517–518, 2000. View at Google Scholar
  10. H.-J. Kim, S.-H. Yeom, M.-K. Kim, J.-G. Shim, I.-N. Paek, and M.-W. Lee, “Nitric oxide and prostaglandin E2 synthesis inhibitory activities of diarylheptanoids from the barks of Alnus japonica steudel,” Archives of Pharmacal Research, vol. 28, no. 2, pp. 177–179, 2005. View at Publisher · View at Google Scholar · View at Scopus
  11. J.-M. Han, S. L. Woo, J.-R. Kim et al., “Effects of diarylheptanoids on the tumor necrosis factor-α-induced expression of adhesion molecules in human umbilical vein endothelial cells,” Journal of Agricultural and Food Chemistry, vol. 55, no. 23, pp. 9457–9464, 2007. View at Publisher · View at Google Scholar · View at Scopus
  12. J.-M. Han, S. L. Woo, J.-R. Kim et al., “Effect of 5-O-methylhirsutanonol on nuclear factor-κB-dependent production of NO and expression of iNOS in lipopolysaccharide-induced RAW264.7 cells,” Journal of Agricultural and Food Chemistry, vol. 56, no. 1, pp. 92–98, 2008. View at Publisher · View at Google Scholar · View at Scopus
  13. C. S. Lee, H. H. Ko, S. J. Seo et al., “Diarylheptanoid hirsutenone prevents tumor necrosis factor-α-stimulated production of inflammatory mediators in human keratinocytes through NF-κB inhibition,” International Immunopharmacology, vol. 9, no. 9, pp. 1097–1104, 2009. View at Publisher · View at Google Scholar · View at Scopus
  14. S. S. Joo, S. G. Kim, S. E. Choi et al., “Suppression of T cell activation by hirsutenone, isolated from the bark of Alnus japonica, and its therapeutic advantages for atopic dermatitis,” European Journal of Pharmacology, vol. 614, no. 1-3, pp. 98–105, 2009. View at Publisher · View at Google Scholar · View at Scopus
  15. M. Uehara and C. Kimura, “Descendant family history of atopic dermatitis,” Acta Dermato-Venereologica, vol. 73, no. 1, pp. 62–63, 1993. View at Google Scholar · View at Scopus
  16. H. P. Van Bever, “Recent advances in the pathogenesis of atopic dermatitis,” European Journal of Pediatrics, vol. 151, no. 12, pp. 870–873, 1992. View at Publisher · View at Google Scholar · View at Scopus
  17. T. Kishimoto and T. Hirano, “Molecular regulation of B lymphocyte response,” Annual Review of Immunology, vol. 6, pp. 485–512, 1988. View at Google Scholar · View at Scopus
  18. U. Reinhold, G. Pawelec, W. Wehrmann, M. Herold, P. Wernet, and H. W. Kreysel, “Immunoglobulin E and immunoglobulin G subclass distribution in vivo and relationship to in vitro generation of interferon-gamma and neopterin in patients with severe atopic dermatitis,” International Archives of Allergy and Applied Immunology, vol. 87, no. 2, pp. 120–126, 1988. View at Google Scholar · View at Scopus
  19. J. L. Ried and A. Collmer, “Comparison of pectic enzymes produced by Erwinia chrysanthemi, Erwinia carotovora subsp. carotovora, and Erwinia carotovora subsp. atroseptica,” Applied and Environmental Microbiology, vol. 52, no. 2, pp. 305–310, 1986. View at Google Scholar · View at Scopus
  20. H. A. Schols and A. G. J. Voragen, “Complex pectins: structure elucidation using enzymes,” in Pectins and Pectinases, J. Visser and A. G. J. Voragen, Eds., pp. 3–19, Elsevier Science BV, Amsterdam, The Netherlands, 1996. View at Google Scholar
  21. H. J. Kim, K. H. Kim, S. H. Yeom et al., “New diarylheptanoid from the barks of Alnus japonica steudel,” Chinese Chemical Letters, vol. 16, no. 10, pp. 1337–1340, 2005. View at Google Scholar · View at Scopus
  22. T. Sasakawa, Y. Higashi, S. Sakuma et al., “Atopic dermatitis-like skin lesions induced by topical application of mite antigens in NC/Nga mice,” International Archives of Allergy and Immunology, vol. 126, no. 3, pp. 239–247, 2001. View at Publisher · View at Google Scholar · View at Scopus
  23. T. Yamaguchi, T. Maekawa, Y. Nishikawa et al., “Characterization of itch-associated responses of NC mice with mite-induced chronic dermatitis,” Journal of Dermatological Science, vol. 25, no. 1, pp. 20–28, 2001. View at Publisher · View at Google Scholar · View at Scopus
  24. H. Matsuda, N. Watanabe, G. P. Geba et al., “Development of atopic dermatitis-like skin lesion with IgE hyperproduction in NC/Nga mice,” International Immunology, vol. 9, no. 3, pp. 461–466, 1997. View at Publisher · View at Google Scholar · View at Scopus
  25. M. Yamamoto, T. Haruna, K. Yasui et al., “A novel atopic dermatitis model induced by topical application with Dermatophagoides farinae extract in NC/Nga mice,” Allergology International, vol. 56, no. 2, pp. 139–148, 2007. View at Publisher · View at Google Scholar · View at Scopus
  26. D. Simon, L. R. Braathen, and H.-U. Simon, “Eosinophils and atopic dermatitis,” Allergy, vol. 59, no. 6, pp. 561–570, 2004. View at Publisher · View at Google Scholar · View at Scopus
  27. Q. Hamid, M. Boguniewicz, and D. Y. M. Leung, “Differential in situ cytokine gene expression in acute versus chronic atopic dermatitis,” Journal of Clinical Investigation, vol. 94, no. 2, pp. 870–876, 1994. View at Google Scholar · View at Scopus
  28. J. D. Ohmen, J. M. Hanifin, B. J. Nickoloff et al., “Overexpression of IL-10 in atopic dermatitis: contrasting cytokine patterns with delayed-type hypersensitivity reactions,” Journal of Immunology, vol. 154, no. 4, pp. 1956–1963, 1995. View at Google Scholar · View at Scopus
  29. P.-O. Fiset, D. Y. M. Leung, and Q. Hamid, “Immunopathology of atopic dermatitis,” Journal of Allergy and Clinical Immunology, vol. 118, no. 1, pp. 287–290, 2006. View at Publisher · View at Google Scholar · View at Scopus
  30. M. Kotani, M. Matsumoto, A. Fujita et al., “Persimmon leaf extract and astragalin inhibit development of dermatitis and IgE elevation in NC/NGa mice,” Journal of Allergy and Clinical Immunology, vol. 106, no. 1 I, pp. 159–166, 2000. View at Publisher · View at Google Scholar · View at Scopus
  31. H. Oku and K. Ishiguro, “Antipruritic and antidermatitic effect of extract and compounds of Impatiens balsamina L. in Atopic dermatitis model NC mice,” Phytotherapy Research, vol. 15, no. 6, pp. 506–510, 2001. View at Publisher · View at Google Scholar · View at Scopus
  32. I. Ziment and D. P. Tashkin, “Alternative medicine for allergy and asthma,” Journal of Allergy and Clinical Immunology, vol. 106, no. 4, pp. 603–614, 2000. View at Google Scholar · View at Scopus
  33. W. Cookson, “The immunogenetics of asthma and eczema: a new focus on the epithelium,” Nature Reviews Immunology, vol. 4, no. 12, pp. 978–988, 2004. View at Publisher · View at Google Scholar · View at Scopus
  34. D. P. Strachan, “Family site, infection and atopy: the first decade of the 'hygiene hypothesis',” Thorax, vol. 55, no. 1, pp. S2–S10, 2000. View at Google Scholar · View at Scopus
  35. M. Yamamoto, T. Haruna, K. Yasui et al., “A novel atopic dermatitis model induced by topical application with Dermatophagoides farinae extract in NC/Nga mice,” Allergology International, vol. 56, no. 2, pp. 139–148, 2007. View at Publisher · View at Google Scholar · View at Scopus