Serum Positive for the Autoantibody against the -Adrenoceptor from Chinese Patients with Congestive Heart Failure Decreases in Mouse Cardiac Myocytes
Figure 1
Effect of AAB-β 1-negative and -positive serum of CHF patients on outward K+ currents of mouse cardiomyocytes: (a), (b), (c), and (d), current traces obtained with 1-s depolarizing step from −50 to +50 mV in 10 mV increments from a holding potential of −60 mV. Voltage protocols are shown below the current traces. Under the present experimental conditions, the peak of the current was , and the end 50 ms of plateau potential current was . (e), (f), corresponding current–voltage relationships during the application of AAB- β 1-negative or -positive serum of CHF patients at the dilution of 1 : 20. AAB-β 1 negative serum had no effect on the activity of , and the corresponding current-voltage curves (b, d, e, f). The AAB- β 1-positive serum had no effect on activity of , but it produced a decrease in the currents of (a, c, e, f).
