Review Article
More Than Just Tumor Destruction: Immunomodulation by Thermal Ablation of Cancer
Table 6
Studies reporting immune modulation in cancer patients and animal models treated with LITT.
| | Species | Tumor | Model | Immunologic Effect | References |
| | Human | CRC () | | IL-6, TNF-R1 (serum)↑ | [130] | | HCC () | | | | | Other () | | | |
| | Mouse (CBA) | Liver metastases of CRC | MoCR | HSP-70 (cytoplasm, nuclear)↑ | [131] | | Subcutaneous CRC tumors | MoCR | CD3+ cells (tumor-host interface)↑ | [132] | | | | Spontaneous IFNγ production (spleen, lymph nodes, tumor, | | | | | and distant tumors)↑ | |
| | Rat (WAG) | CRC | CC531 | CD8, CD86, MHC-II, CD11a, and ICAM1 expression (invasion | [128] | | | | front of distant tumors)↑ | |
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