Immunopathology of Postprimary Tuberculosis: Increased T-Regulatory Cells and DEC-205-Positive Foamy Macrophages in Cavitary Lesions
Figure 3
Immunopathology of cavitary lesions. (a) Early cavitary lesion, surrounded by lipid pneumonia, 100x. (b) Chronic cavitary lesion. The cavity wall consists of necrotic material, foamy macrophages, and fibrous tissue with abundant lymphocytes, 100x. (c) Numerous CD4+ cells make up the lymphocytic portion of a cavity wall, 100x. (d) CD8+ cells in the wall of a cavity, 100x. (e) CD20+ cells in the wall of a cavitary lesion, 100x. (f) The cells lining the cavity are CD68+ macrophages, 100x. (g) Foamy macrophages lining the cavity wall are positive for the dendritic cell marker DEC-205, 400x. Insert demonstrates a region detailing the staining for DEC-205. (h) Numerous Foxp3+ cells (arrow) were found in the cavity wall, 400x. (i) Abundant granulation tissue in the wall of a cavitary lesion noted with the CD31 stain, 100x.
