Innate Immune Effectors in Mycobacterial Infection
Figure 1
Recognition of mycobacteria by Toll-like receptors. TLR2 recognizes several mycobacterial-derived components. TLR9 recognizes mycobacterial DNA including the CpG motif within endosomal compartments. TLR-dependent recognition of mycobacteria induces activation of signaling pathways via the adaptor molecule MyD88, leading to activation of gene expression.