Modulation of Cytokine and Cytokine Receptor/Antagonist by Treatment with Doxycycline and Tetracycline in Patients with Dengue Fever

Table 1

Effect of Doxycycline and Tetracycline on cytokine levels and IL1-RA and S TNF-R1 in patients with dengue fever.

Treatment group (GMT and ranges, pg/mL)
	Control			Doxycycline			Tetracycline
	Day 0	Day 3	Day 7	Day 0	Day 3	Day 7	Day 0	Day 3	Day 7
IL-6	6.99	7.58	7.41	7.47	5.98^∗	3.96^∗	7.38	6.36^∗	5.48^∗
	(5.59–8.32)	(6.24–8.98)	(4.18–9.30)	(6.28–9.16)	(3.70–7.98)	(2.32–6.89)	(5.33–9.39)	(4.72–7.90)	(3.89–7.07)
IL-1𝛽	4.53	4.95	4.64	4.53	2.29^∗	1.55^∗	4.41	3.36^∗	2.23^∗
	(3.32–6.30)	(3.67–6.54)	(2.25–6.43)	(3.35–6.36)	(1.23–4.12)	(1.10–2.78)	(3.15–6.27)	(1.48–5.43)	(1.02–4.69)
IL1 RA	325	344	349	264	673^∗	964^∗	263	330^∗	404^∗
	(189–632)	(202–714)	(199–699)	(187–381)	(486–851)	(701–1459)	(184–366)	(201–732)	(231–920)
TNF	4.38	5.02	5.20	4.46	2.42^∗	0.90^∗	4.37	3.89^∗	3.31^∗
	(2.69–6.43)	(2.85–7.89)	(3.10–8.21)	(2.66–6.54)	(0.23–4.63)	(0.4–3.02)	(2.67–6.22)	(2.03–5.65)	(1.19–5.08)
TNF R1	1751	2074	2189	1969	2432^†	2616^†	1816	2115^†	2324^†
	(989–2899)	(1143–3304)	(1200–3278)	(298–3312)	(673–3762)	(1021–4412)	(1099–2766)	(1358–3282)	(1409–3974)

^∗(𝑃<.01).
^†(𝑃>.05).