Journal of Immunology Research / 2011 / Article / Tab 1

Clinical Study

Modulation of Cytokine and Cytokine Receptor/Antagonist by Treatment with Doxycycline and Tetracycline in Patients with Dengue Fever

Table 1

Effect of Doxycycline and Tetracycline on cytokine levels and IL1-RA and S TNF-R1 in patients with dengue fever.

Treatment group (GMT and ranges, pg/mL)

ControlDoxycyclineTetracycline

Day 0Day 3Day 7Day 0Day 3Day 7Day 0Day 3Day 7

IL-6 6.99 7.58 7.41 7.47 7.38
(5.59–8.32)(6.24–8.98)(4.18–9.30)(6.28–9.16)(3.70–7.98)(2.32–6.89)(5.33–9.39)(4.72–7.90)(3.89–7.07)
IL-1 4.53 4.95 4.64 4.53 4.41
(3.32–6.30)(3.67–6.54)(2.25–6.43)(3.35–6.36)(1.23–4.12)(1.10–2.78)(3.15–6.27)(1.48–5.43)(1.02–4.69)
IL1 RA 325 344 349 264 263
(189–632)(202–714)(199–699)(187–381)(486–851)(701–1459)(184–366)(201–732)(231–920)
TNF 4.38 5.02 5.20 4.46 4.37
(2.69–6.43)(2.85–7.89)(3.10–8.21)(2.66–6.54)(0.23–4.63)(0.4–3.02)(2.67–6.22)(2.03–5.65)(1.19–5.08)
TNF R1 1751 2074 2189 1969 1816
(989–2899)(1143–3304)(1200–3278)(298–3312)(673–3762) (1021–4412)(1099–2766)(1358–3282)(1409–3974)

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