Modulation of Cytokine and Cytokine Receptor/Antagonist by Treatment with Doxycycline and Tetracycline in Patients with Dengue Fever

Table 2

Effect of Doxycycline and Tetracycline on cytokine levels and IL1-RA and S TNF-R1 in patients with dengue hemorrhagic fever.

Treatment group (GMT and ranges, pg/mL)
	Control			Doxycycline			Tetracycline
	Day 0	Day 3	Day 7	Day 0	Day 3	Day 7	Day 0	Day 3	Day 7
IL-6	4.75	5.22	5.20	5.54	3.84^∗	2.36^∗	5.11	4.68^∗	4.23^∗
	(3.28–7.24)	(3.24–7.89)	(3.27–8.04)	(3.42–7.65)	(2.01–6.73)	(1.24–5.38)	(3.27–7.28)	(2.93–6.98)	(2.46–6.66)
IL-1𝛽	6.88	7.83	8.07	7.56	5.32^∗	3.29^∗	7.97	7.68^∗	7.22^∗
	(3.32–9.32)	(4.61–10.43)	(3.25–10.56)	(4.84–10.30)	(3.21–8.53)	(1.21–6.48)	(6.01–9.81)	(5.59–9.44)	(5.21–9.32)
IL1 RA	494	611	676	335	710^∗	996^∗	497	517^†	510^†
	(314–671)	(307–812)	(455–981)	(221–472)	(462–928)	(703–1532)	(285–672)	(342–695)	(342–714)
TNF	7.76	8.44	8.50	6.97	5.31^∗	4.31^∗	8.05	7.83^∗	7.54^∗
	(6.11–10.20)	(6.72–11.28)	(6.02–11.10)	(1.12–11.01)	(0.46–12.32)	(1.04–7.94)	(6.28–9.73)	(5.99–9.62)	(5.71–9.17)
TNF R1	1593	1719	1796	1497	1961^∗	2367^∗	1631	1736^†	1853^†
	(1284–1902)	(1273–2135)	(1279–2387)	(1212–1843)	(1538–2985)	(1759–3129)	(1271–1961)	(1329–2116)	(1365–2362)

^∗(𝑃<.01).
^†(𝑃>.05).