Journal of Immunology Research / 2011 / Article / Tab 2

Clinical Study

Modulation of Cytokine and Cytokine Receptor/Antagonist by Treatment with Doxycycline and Tetracycline in Patients with Dengue Fever

Table 2

Effect of Doxycycline and Tetracycline on cytokine levels and IL1-RA and S TNF-R1 in patients with dengue hemorrhagic fever.

Treatment group (GMT and ranges, pg/mL)

ControlDoxycyclineTetracycline

Day 0Day 3Day 7Day 0Day 3Day 7Day 0Day 3Day 7

IL-6 4.75 5.22 5.20 5.54 5.11
(3.28–7.24)(3.24–7.89)(3.27–8.04)(3.42–7.65)(2.01–6.73)(1.24–5.38)(3.27–7.28)(2.93–6.98)(2.46–6.66)
IL-1 6.88 7.83 8.07 7.56 7.97
(3.32–9.32)(4.61–10.43)(3.25–10.56)(4.84–10.30)(3.21–8.53)(1.21–6.48)(6.01–9.81)(5.59–9.44)(5.21–9.32)
IL1 RA 494 611 676 335 497
(314–671)(307–812)(455–981) (221–472)(462–928)(703–1532)(285–672)(342–695)(342–714)
TNF 7.76 8.44 8.50 6.97 8.05
(6.11–10.20)(6.72–11.28)(6.02–11.10)(1.12–11.01)(0.46–12.32)(1.04–7.94)(6.28–9.73)(5.99–9.62)(5.71–9.17)
TNF R1 1593 1719 1796 1497 1631
(1284–1902)(1273–2135)(1279–2387)(1212–1843)(1538–2985)(1759–3129)(1271–1961)(1329–2116)(1365–2362)

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