Modulation of Cytokine and Cytokine Receptor/Antagonist by Treatment with Doxycycline and Tetracycline in Patients with Dengue Fever

Table 3

Differential effect of Doxycycline and Tetracycline on cytokine levels and IL1-RA and S TNF-R1 in patients with dengue fever and dengue hemorrhagic fever.

Dengue fever (GMT and ranges, pg/mL)					DHF (GMT and ranges, pg/mL)
	Doxycycline		Tetracycline		Doxycycline		Tetracycline
	Day 3	Day 7	Day 3	Day 7	Day 3	Day 7	Day 3	Day 7
IL-6	5.98^†	3.96*	6.36	5.48	3.84*	2.36*	4.68	4.23
	(3.70–7.98)	(2.32–6.89)	(4.72–7.90)	(3.89–7.07)	(2.01–6.73)	(1.24–5.38)	(2.93–6.98)	(2.46–6.66)
IL-1𝛽	2.29*	1.55*	3.36	2.23	5.32*	3.29*	7.68	7.22
	(1.23–4.12)	(1.10–2.78)	(1.48–5.43)	(1.02–4.69)	(3.21–8.53)	(1.21–6.48)	(5.59–9.44)	(5.21–9.32)
IL-1 RA	673*	964*	330	404	710*	996*	517	510
	(486–851)	(701–1459)	(201–732)	(231–920)	(462–928)	(703–1532)	(342–695)	(342–714)
TNF	2.42*	0.90*	3.89	3.31	5.31*	4.31*	7.83	7.54
	(0.23–4.63)	(0.4–3.02)	(2.03–5.65)	(1.19–5.08)	(0.46–12.32)	(1.04–7.94)	(5.99–9.62)	(5.71–9.17)
TNF R1	2432*	2616^€	2115	2324	1961*	2367*	1736	1853
	(673–3762)	(1021–4412)	(1358–3282)	(1409–3974)	(1538–2985)	(1759–3129)	(1329–2116)	(1365–2362)

^€(𝑃<.05).
^∗(𝑃<.01).
^†(𝑃>.05).