Innate Immune Recognition of Mycobacterium tuberculosis

Table 1

SNPs associated with susceptibility to tuberculosis.

Receptor/signalling pathway	Gene	Amino acid	Association	No association
TLR1	1805T>G	Lle602Ser	[94]	[95]
TLR2	816T>C	Asn199Asn
	2258G>A	Arg753Gln	[86]	[95]
	196 to 174 I/D*	—	[96]	[87, 89, 91]
TLR4	13843A>G	Asp299Gly	[97, 98]	[95, 99]
	1196C>T	Thr399Ile		[95, 97]
TLR6	1083G>C	Thr361Thr	[100]
	745C>T	Ser249Pro	[100]	[95]
TLR8	4959C>G	—	[40]
	2921A>G	—	[40]
	3943A>G	—	[40]
	5088A>G	Met1Val	[40]
TLR9	588A>G	Lys196Lys	[96]
	411C>T	His137His	[96]
TIRAP	539C>T	Ser180Leu	[101]	[102]
DC-SIGN	336A>G	—	[103, 104]	[105, 106]
	601C>T	—		[103, 105]
	871G>C	—	[103]	[105]
	939C>T	—		[103, 105]
	Neck	—
	region		[103, 105, 106]
	length

*I/D insertion/deletion.