The Dendritic Cell-Regulatory T Lymphocyte Crosstalk Contributes to Tumor-Induced Tolerance

<table>Bidirectional communications between Treg and tolerogenic DCs in cancer. Tumor-derived factors can promote the differentiation of immature DCs and naïve T cells into tolerogenic DCs and Treg. Tolerogenic DCs contribute to the generation of Treg by various mechanisms.  In turn, Treg participate in tumor-induced tolerance by restraining DC maturation and fostering the accumulation of tolerogenic DCs.</table>

Journal of Immunology Research

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Figure 1: The Dendritic Cell-Regulatory T Lymphocyte Crosstalk Contributes to Tumor-Induced Tolerance 