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Clinical and Developmental Immunology
Volume 2011, Article ID 439053, 15 pages
http://dx.doi.org/10.1155/2011/439053
Review Article

From Tumor Immunosuppression to Eradication: Targeting Homing and Activity of Immune Effector Cells to Tumors

1Molecular Virology Section, Department of Medical Microbiology, University Medical Center Groningen (UMCG), University of Groningen, HPC EB88, P.O. Box 30.001, 9700 RB Groningen, The Netherlands
2Department of Gynecology, University Medical Center Groningen, University of Groningen, 9700 RB Groningen, The Netherlands

Received 30 June 2011; Accepted 6 September 2011

Academic Editor: D. Craig Hooper

Copyright © 2011 Oana Draghiciu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Unraveling the mechanisms used by the immune system to fight cancer development is one of the most ambitious undertakings in immunology. Detailed knowledge regarding the mechanisms of induction of tolerance and immunosuppression within the tumor microenvironment will contribute to the development of highly effective tumor eradication strategies. Research within the last few decades has shed more light on the matter. This paper aims to give an overview on the current knowledge of the main tolerance and immunosuppression mechanisms elicited within the tumor microenvironment, with the focus on development of effective immunotherapeutic strategies to improve homing and activity of immune effector cells to tumors.