Schematic representation of asbestos-induced reduction of expression of a chemokine receptor, CXCR3, and expression and production of IFN-γ using the MT-2 cell line model (Org; MT-2 original cell line, and Rst: sublines exposed continuously to a low-dose of chrysotile), an ex vivo exposure model using freshly isolated CD4+ T cells from healthy donors (HD), as well as analyses of freshly isolated CD4+ T cells from healthy donors and patients with pleural plaque (PP) and malignant mesothelioma (MM).
