T Cell Recognition of Autoantigens in Human Type 1 Diabetes: Clinical Perspectives

Table 4

CD8⁺ T-cell epitopes of human T1D autoantigens (other than preproinsulin).

Epitope preproinsulin	MHC restriction	responders	references
GAD114-123	HLA-A*0201	Recent-onset T1D	[38, 96, 103]
		Transgenic mice
GAD114-122	HLA-A*0201	Recent-onset T1D	[101]
GAD110-118	HLA-A*0201	Transgenic mice	[103]
GAD159-167	HLA-A*0201	Transgenic mice	[103]
GAD476-484	HLA-A*0201	Transgenic mice	[103]
GAD536-545	HLA-A*0201	Transgenic mice	[103]
IAPP5-13	HLA-A*0201	Recent-onset T1D	[98]
IAPP9-17	HLA-A*0201	At risk	[99, 100]
		Recent-onset T1D
		T1D
IGRP215-223	HLA-A*0201	Recent-onset T1D	[100]
IGRP152-160	HLA-A*0201	At risk	[99, 100]
		T1D
IGRP228-236	HLA-A*0201	Transgenic mice	[96, 102]
		Recent-onset T1D
IGRP266-273	HLA-A*0201	Transgenic mice	[96, 102]
		Recent-onset T1D
IGRP206-214	HLA-A*0201	Transgenic mice	[102]
IGRP337-345	HLA-A*0201	Transgenic mice	[102]
IGRP265-273	HLA-A*0201	Transgenic mice	[102]
GFAP143-151	HLA-A*0201	At risk	[99]
		T1D
GFAP214-222	HLA-A*0201	At risk	[99]
		T1D
IA-2797-805		Normal subjects	[97]
		Recent-onset T1D
IA-2172-180	HLA-A*0201	Recent-onset T1D	[100]
IA-2482-490	HLA-A*0201	Recent-onset T1D	[100]
IA2790-798	HLA-A*0201	Transgenic mice	[103]
IA2805-813	HLA-A*0201	Transgenic mice	[103]
IA2830-839	HLA-A*0201	Transgenic mice	[103]
IA2962-970	HLA-A*0201	Transgenic mice	[103]