The Role of CXCR3 in the Induction of Primary Biliary Cirrhosis

Figure 5

Serial observation of mononuclear cells infiltration in the liver tissue. Female C57BL/6 mice were injected with 5 mg/kg of poly I:C twice a week for 24 consecutive weeks. Liver specimens were collected at 8 weeks (a–d), 16 weeks (e–h), and 24 weeks (i–l) after the start of poly I:C injection and were underwent HE staining. Different degrees of lymphocytic infiltration surrounding the small bile ducts were detected within the portal tracts. A representative staining pattern from each period is shown as following: (a, b) Week 8 of WT PBC mice. (c, d) Week 8 of CXCR3^−/− PBC mice. (e, f) Week 16 of WT PBC mice. (g, h) Week 16 of CXCR3^−/− PBC mice. (I, k) Week 24 of WT PBC mice. (j, l) Week 24 of CXCR3^−/− PBC mice. Note: Magnification: (a, c, e, g, i, j) × 5; (b, d, f, h, k, l) × 20, × 40.

(a)

(b)

(c)

(d)

(e)

(f)

(g)

(h)

(i)

(j)

(k)

(l)