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Clinical and Developmental Immunology
Volume 2011 (2011), Article ID 565187, 12 pages
Review Article

Tumor Cells and Tumor-Associated Macrophages: Secreted Proteins as Potential Targets for Therapy

Center for Oncological Research Antwerp (CORE), University of Antwerp, Universiteitsplein 1, 2610 Wilrijk, Belgium

Received 1 July 2011; Revised 9 September 2011; Accepted 20 September 2011

Academic Editor: Nejat Egilmez

Copyright © 2011 Marc Baay et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Inflammatory pathways, meant to defend the organism against infection and injury, as a byproduct, can promote an environment which favors tumor growth and metastasis. Tumor-associated macrophages (TAMs), which constitute a significant part of the tumor-infiltrating immune cells, have been linked to the growth, angiogenesis, and metastasis of a variety of cancers, most likely through polarization of TAMs to the M2 (alternative) phenotype. The interaction between tumor cells and macrophages provides opportunities for therapy. This paper will discuss secreted proteins as targets for intervention.