Immunogenicity and Protective Efficacy against Murine Tuberculosis of a Prime-Boost Regimen with BCG and a DNA Vaccine Expressing ESAT-6 and Ag85A Fusion Protein
Figure 7
Bacterial load per lung and spleen in C57BL/6 mice at 4 weeks after challenge (n = 7). Vaccinated C57BL/6 mice (n = 7) were challenged i.v. with 106 CFU virulent M. tuberculosis H37Rv strain. Four weeks after challenge, lungs and spleens were harvested aseptically and numbers of bacterial CFU per organ were enumerated. Results are shown as the mean (±SEM) log10 CFU/organ. * versus control; ** versus BCG. This experiment was repeated twice with similar results.
