The Therapeutic Effect of Cytokine-Induced Killer Cells on Pancreatic Cancer Enhanced by Dendritic Cells Pulsed with K-Ras Mutant Peptide
Figure 7
The cytotoxicity of K-ras-DCCIK against PANC-1 (K-ras+) and SW1990 (K-ras−) cells at different ratio in vitro (experiment 2.7). It was found that when effector-target ratio reached 1 : 12.5 and 1 : 25, K-ras-DCCIKs’ inhibition to PANC-1 was stronger than that to SW1990 (). However, ratio at 1 : 6.25 and 1 : 50, K-ras-DCCIKs’ inhibition to these two cells showed no statistical difference (). It is demonstrated that CIK cells have a potential to uptake tumor antigens, and further, to produce specific killing effect on PANC-1, there might be some antigen-specific CTL cell subsets existing in K-ras-DCCIKs.
