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Clinical and Developmental Immunology
Volume 2011 (2011), Article ID 686597, 9 pages
http://dx.doi.org/10.1155/2011/686597
Review Article

IL-12 and Related Cytokines: Function and Regulatory Implications in Candida albicans Infection

1The School of Dentistry, University of Queensland School of Dentistry, 200 Turbot Street, Brisbane, QLD 4000, Australia
2The National Centre for Adult Stem Cell Research, Eskitis Institute for Cell and Molecular Therapies, Griffith University, Brisbane, QLD 4111, Australia

Received 15 June 2010; Revised 1 August 2010; Accepted 21 September 2010

Academic Editor: David Williams

Copyright © 2011 Robert B. Ashman et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

IL-12 is a cytokine with links to both innate and adaptive immunity systems. In mice, its deletion leads to acute susceptibility to oral infection with the yeast Candida albicans, whereas such mice are resistant to systemic disease. However, it is an essential component of the adaptive response that leads to the generation of Th1-type cytokine responses and protection against disseminated disease. This paper presents an overview of the role of IL-12 in models of systemic and mucosal infection and the possible relationships between them.