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Clinical and Developmental Immunology
Volume 2011, Article ID 730828, 6 pages
http://dx.doi.org/10.1155/2011/730828
Research Article

Dexamethasone Prophylaxis in Pediatric Open Heart Surgery Is Associated with Increased Blood Long Pentraxin PTX3: Potential Clinical Implications

1Division of Cardiovascular Surgery, G. Gaslini Institute, IRCCS, Largo G. Gaslini 5, 16148 Genoa, Italy
2Department of Immunology and Inflammation, Istituto Clinico Humanitas, IRCCS, Via Manzoni 56, 20089 Rozzano, Milan, Italy
3Laboratory of Oncology, G. Gaslini Institute, IRCCS, Largo G. Gaslini 5, 16148 Genoa, Italy
4Clinical Epidemiology and Biostatistics Unit, G. Gaslini Institute, IRCCS, Largo G. Gaslini 5, 16148 Genoa, Italy
5Dipartimento di Medicina Traslazionale, University of Milan, Via Manzoni 56, 20089 Rozzano, Milan, Italy

Received 12 November 2010; Accepted 2 May 2011

Academic Editor: Luigina Romani

Copyright © 2011 Franco Lerzo et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Glucocorticoid administration before cardiopulmonary bypass (CPB) can reduce the systemic inflammatory response and improve clinical outcome. Long pentraxin PTX3 is a novel inflammatory parameter that could play a protective cardiovascular role by regulating inflammation. Twenty-nine children undergoing open heart surgery were enrolled in the study. Fourteen received dexamethasone (1st dose 1.5 mg/Kg i.v. or i.m. the evening before surgery; 2nd dose 1.5 mg/kg i.v. before starting bypass) and fifteen children served as control. Blood PTX3, short pentraxin C-reactive protein (CRP), interleukin-1 receptor II (IL-1RII), fibrinogen and partial thromboplastin time (PTT) were assayed at different times. PTX3 levels significantly increased during CPB in dexamethasone-treated (+D) and dexamethasone-untreated (−D) subjects, but were significantly higher in +D than −D patients. CRP levels significantly increased both in +D and −D patients in the postoperative days, with values significantly higher in −D than +D patients. Fibrinogen and PTT values were significantly higher in −D than +D patients in the 1st postoperative day. IL-1RII plasma levels increased in the postoperative period in both groups. Dexamethasone prophylaxis in pediatric patients undergoing CPB for cardiac surgery is associated with a significant increase of blood PTX3 that could contribute to decreasing inflammatory parameters and improving patient clinical outcome.