Comparative Approach to Define Increased Regulatory T Cells in Different Cancer Subtypes by Combined Assessment of CD127 and FOXP3
Assessment of Treg-cell frequencies. Frequency of CD4+CD25highFOXP3+ Treg cells in (a) peripheral blood of 10 healthy donors (control), 12 colorectal cancer (CRC), 10 CLL, 7 MGUS, and 10 multiple myeloma (MM) patients and (b) 7 reactive lymph node biopsies from healthy individuals (reactive), 7 patients with follicular lymphoma (FL), and 6 patients with Hodgkin’s disease (HD). (c) and (d) Frequencies of CD4+CD127lowFOXP3+ Treg cells in the respective groups. Error bars represent standard deviation (*, , Student’s t test).