Clinical Study
Comparative Approach to Define Increased Regulatory T Cells in Different Cancer Subtypes by Combined Assessment of CD127 and FOXP3
Table 3
Assessment of Treg-cell frequencies in peripheral blood.
| | Control | Colon | CLL | MGUS | MM | | Mean (SD) | Mean (SD) | | Mean (SD) | | Mean (SD) | | Mean (SD) | |
| CD4+ CD127low | 4.6 (1.3) | 7.6 (1.5) | <0.001 | 8.3 (2.5) | <0.005 | 5.4 (1.3) | n.s. | 11.2 (5.9) | <0.01 | CD4+ CD127lowFOXP3+ | 4.1 (0.7) | 7.2 (2.4) | <0.005 | 8.9 (4.0) | <0.005 | 6.0 (1.8) | <0.05 | 11.7 (5.4) | <0.005 | CD4+ CD127lowFOXP3+ CD25high | 2.5 (0.6) | 4.3 (1.6) | <0.005 | 4.7 (2.7) | <0.05 | 3.9 (1.3) | <0.05 | 7.1 (4.9) | <0.05 | CD4+ CD25high | 2.8 (0.9) | 7.6 (1.2) | <0.001 | 6.4 (1.8) | <0.001 | 4.5 (1.1) | <0.05 | 9.0 (5.3) | <0.01 | CD4+ CD25highCD127low | 2.9 (0.9) | 4.5 (1.2) | <0.005 | 4.5 (2.0) | <0.05 | 3.5 (1.3) | n.s. | 7.0 (5.1) | <0.05 | CD4+ CD25highFOXP3+ | 2.1 (0.8) | 4.2 (1.2) | <0.001 | 3.6 (1.7) | <0.05 | 2.5 (0.6) | n.s. | 6.3 (4.5) | <0.05 | CD4+ FOXP3+ | 2.8 (0.9) | 4.7 (2.1) | <0.05 | 4.7 (2.4) | <0.05 | 3.6 (1.1) | n.s. | 7.7 (5.1) | <0.05 |
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Definition of subpopulations based on expression of CD25, CD127, and FOXP3 (SD: standard deviation, n.s.: not significant).
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