Lactobacillus paracasei Reduces Intestinal Inflammation in Adoptive Transfer Mouse Model of Experimental Colitis
Figure 6
Gene expression analysis in colonic samples. Colonic mRNA expressions of tight junction proteins (Claudin-2, -15, occluding, ZO-1, and -2), antimicrobial peptides (defensin β-1, β-2, lysozyme, reg3β, reg3γ, RELMβ, and secretory phospholipase A2), and cytokines (IL1β, IL-6, IL-8, IL-12, IL-23, TNFα, TGFβ, IFNγ, IL-17A, IL17F, and IL-22) were evaluated in PBS-fed or ST11-fed colitic mice and given in the lower red and black bar graphs, respectively. GAPDH was used as a reference gene. Ratios between ST11-fed and PBS-fed mice are shown in the upper inverted bar graphs, respectively. For a given gene, mRNA expression is either decreased when the ratio <1 or increased when the ratio >1 in ST11-fed animals. : tendancy *, , and ** versus PBS-fed mice.
