Journal of Immunology Research / 2011 / Article / Tab 1

Review Article

Pathogenesis, Immunology, and Diagnosis of Latent Mycobacterium tuberculosis Infection

Table 1

Some important M. tuberculosis factors that modulate the innate immune response and promote persistence of the pathogen leading to latent tuberculosis infection.

M. tuberculosis componentImmune cell process inhibited/affectedReference(s)

19 kDa Lipoprotein (LpqH)MHC class II expression and antigen presentation[32, 44, 8587]
19 kDa Lipoprotein (LpqH)Phagosomal processing by MHC class I pathway[88]
Mannose capped lipoarabinomannanPhagolysosome biogenesis[46, 89, 90]
Mannose capped lipoarabinomannanMHC class II expression and antigen presentation[85, 90]
Mannose capped lipoarabinomannanIL-12 secretion of dentritic cells/macrophages[45, 90]
Mannose capped lipoarabinomannanApoptosis of macrophages[90, 91]
Trehalose dimycolate (cord factor)Phagolysosome biogenesis[92, 93]
Trehalose dimycolate (cord factor)MHC class II expression and antigen presentation[94]
6-kDa early secreted antigenic target (ESAT-6)Pathogen containment in phagolysosome/macrophage[9597]
ESX-1 secreted proteinsMacrophage proinflammatory cytokine response[98]
Serine/threonine protein kinase G (PknG)Phagolysosome biogenesis[99, 100]
Lipid phosphatase (SapM)Phagolysosome biogenesis[101]
Lipoprotein LprAMHC class II expression and antigen presentation[36]
Lipoprotein LprGMHC class II expression and antigen presentation[35]
Secretion system SecA2Apoptosis of macrophages and dendritic cells[102]
Superoxide dismutase (SodA)Apoptosis of macrophages and dendritic cells[102]
NADH dehydrogenase (NuoG)Apoptosis of macrophages and dendritic cells[103]

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