Th2 Regulation of Viral Myocarditis in Mice: Different Roles for TLR3 versus TRIF in Progression to Chronic Disease
Figure 1
Inflammation and viral replication increase in a similar manner in TLR3-deficient (TLR3−/−) or TRIF−/− mice during acute CVB3 myocarditis. (a) TLR3−/− mice developed increased inflammation and viral replication at day 10 pi compared to WT B6.129 controls. (a) Representative histology sections of inflammation in WT and TLR3−/− hearts stained with H&E (top), magnification . (b) TRIF−/− mice develop increased inflammation and viral replication at day 10 pi compared to WT BL/6 controls. (b) Representative histology sections of inflammation in WT and TRIF−/− hearts stained with H&E (top), magnification . Data show the mean ± SEM of at least three separate experiments using 7 to 12 mice/group. **, ***.
