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Clinical and Developmental Immunology
Volume 2012 (2012), Article ID 139127, 14 pages
http://dx.doi.org/10.1155/2012/139127
Review Article

The Tuberculous Granuloma: An Unsuccessful Host Defence Mechanism Providing a Safety Shelter for the Bacteria?

INSERM U892, CNRS UMR 6299, Université de Nantes, 44007 Nantes Cedex 1, France

Received 9 December 2011; Revised 16 April 2012; Accepted 30 April 2012

Academic Editor: E. Shevach

Copyright © 2012 Mayra Silva Miranda et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Citations to this Article [55 citations]

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  • Toshihiro Ito, Judith M. Connett, Steven L. Kunkel, and Akihiro Matsukawa, “The linkage of innate and adaptive immune response during granulomatous development,” Frontiers in Immunology, vol. 4, 2012. View at Publisher · View at Google Scholar
  • S. Danaviah, J.A. Sacks, K.P.S. Kumar, L.M. Taylor, D.A. Fallows, T. Naicker, T. Ndung'u, S. Govender, and G. Kaplan, “Immunohistological characterization of spinal TB granulomas from HIV-negative and -positive patients,” Tuberculosis, 2013. View at Publisher · View at Google Scholar
  • Colin S. Brown, and Nicholas M. Price, “The immunopathology of tuberculosis - An update,” Current Respiratory Medicine Reviews, vol. 9, no. 3, pp. 151–155, 2013. View at Publisher · View at Google Scholar
  • Khalid Ahmed Al-Anazi, Asma Marzouq Al-Jasser, and Khalid Alsaleh, “Infections Caused by Mycobacterium tuberculosis in Recipients of Hematopoietic Stem Cell Transplantation,” Frontiers in Oncology, vol. 4, 2014. View at Publisher · View at Google Scholar
  • Libin Shi, Gavin J. Ryan, Suresh Bhamidi, JoLynn Troudt, Anita Amin, Angelo Izzo, Anne J. Lenaerts, Michael R. McNeil, John T. Belisle, Dean C. Crick, and Delphi Chatterjee, “Isolation and Purification of Mycobacterium tuberculosis from H37Rv Infected Guinea Pig Lungs,” Tuberculosis, 2014. View at Publisher · View at Google Scholar
  • Shajila Siricilla, Katsuhiko Mitachi, Karolina Skorupinska-Tudek, Ewa Swiezewska, and Michio Kurosu, “Biosynthesis of A Water-Soluble Lipid I Analogue and A Convenient Assay for Translocase I,” Analytical Biochemistry, 2014. View at Publisher · View at Google Scholar
  • Monika Prochorec-Sobieszek, and Ewa Lech-Maranda, “Hodgkin's Lymphoma Mimicking Tuberculosis In Cervical Lymph Nodes,” Polish Journal of Pathology, vol. 65, no. 1, pp. 83–88, 2014. View at Publisher · View at Google Scholar
  • Véronique Dartois, “The path of anti-tuberculosis drugs: from blood to lesions to mycobacterial cells,” Nature Reviews Microbiology, 2014. View at Publisher · View at Google Scholar
  • Zhiwei Wang, Xiaoguang Li, Jie Pan, Huadan Xue, Zhengyu Jin, Haifeng Shi, Xiaobo Zhang, Wei Liu, and Ning Yang, “Role of CT-guided transthoracic core needle biopsy in the diagnosis of pulmonary tuberculosis,” Radiology of Infectious Diseases, 2014. View at Publisher · View at Google Scholar
  • Marilena Paola Etna, Elena Giacomini, Martina Severa, and Eliana Marina Coccia, “Pro- and anti-inflammatory cytokines in TB: A two-edged sword in TB pathogenesis,” Seminars in Immunology, 2014. View at Publisher · View at Google Scholar
  • Shajila Siricilla, Katsuhiko Mitachi, Bajoie Wan, Scott G Franzblau, and Michio Kurosu, “Discovery of a capuramycin analog that kills nonreplicating Mycobacterium tuberculosis and its synergistic effects with translocase I inhibitors,” The Journal of Antibiotics, 2014. View at Publisher · View at Google Scholar
  • Liam E. Fitzgerald, Naiara Abendaño, Ramon A. Juste, and Marta Alonso-Hearn, “Three-Dimensional In Vitro Models of Granuloma to Study Bacteria-Host Interactions, Drug-Susceptibility, and Resuscitation of Dormant Mycobacteria,” BioMed Research International, vol. 2014, pp. 1–8, 2014. View at Publisher · View at Google Scholar
  • Kiran I. Masood, Shahid Pervez, Martin E. Rottenberg, Beena Umar, and Zahra Hasan, “Suppressor of cytokine signaling-1 and chemokine (C-X-C Motif) receptor 3 expressions are associated with caseous necrosis in granulomas from patients with tuberculous lymphadenitis,” Journal of Microbiology, Immunology and Infection, 2015. View at Publisher · View at Google Scholar
  • Selvakumar Subbian, Liana Tsenova, Mi-Jeong Kim, Helen C. Wainwright, Annalie Visser, Nirmalya Bandyopadhyay, Joel S. Bader, Petros C. Karakousis, Gabriele B. Murrmann, Linda-Gail Bekker, David G. Russell, and Gilla Kaplan, “Lesion-Specific Immune Response in Granulomas of Patients with Pulmonary Tuberculosis: A Pilot Study,” Plos One, vol. 10, no. 7, 2015. View at Publisher · View at Google Scholar
  • Zikun Huang, Qing Luo, Yang Guo, Jie Chen, Guoliang Xiong, Yiping Peng, Jianqing Ye, and Junming Li, “Mycobacterium tuberculosis-Induced Polarization of Human Macrophage Orchestrates the Formation and Development of Tuberculous Granulomas In Vitro,” Plos One, vol. 10, no. 6, 2015. View at Publisher · View at Google Scholar
  • M.J.H. O’Hagan, E.A. Courcier, J.A. Drewe, A.W. Gordon, J. McNair, and D.A. Abernethy, “Risk factors for visible lesions or positive laboratory tests in bovine tuberculosis reactor cattle in Northern Ireland,” Preventive Veterinary Medicine, 2015. View at Publisher · View at Google Scholar
  • JoAnne L. Flynn, Hannah P. Gideon, Joshua T. Mattila, and Philana Ling Lin, “Immunology studies in non-human primate models of tuberculosis,” Immunological Reviews, vol. 264, no. 1, pp. 60–73, 2015. View at Publisher · View at Google Scholar
  • Agnieszka Krupa, Marek Fol, Bozena R. Dziadek, Ewa Kepka, Dominika Wojciechowska, Anna Brzostek, Agnieszka Torzewska, Jaroslaw Dziadek, Robert P. Baughman, David Griffith, and Anna K. Kurdowska, “ Binding of CXCL8/IL-8 to Mycobacterium tuberculosis Modulates the Innate Immune Response ,” Mediators of Inflammation, vol. 2015, pp. 1–11, 2015. View at Publisher · View at Google Scholar
  • Jeffrey K. Actor, “Lactoferrin: A Modulator for Immunity against Tuberculosis Related Granulomatous Pathology,” Mediators of Inflammation, vol. 2015, pp. 1–10, 2015. View at Publisher · View at Google Scholar
  • Arshad Khan, Robert L. Hunter, and Chinnaswamy Jagannath, “Emerging role of mesenchymal stem cells during tuberculosis: The fifth element in cell mediated immunity,” Tuberculosis, 2016. View at Publisher · View at Google Scholar
  • Jenny K. W. Lam, Susan W. S. Leung, Wanling Liang, and Yingshan Qiu, “Delivery of RNAi therapeutics to the airways - From bench to bedside,” Molecules, vol. 21, no. 9, 2016. View at Publisher · View at Google Scholar
  • Mani H. Vemula, Raghavender Medisetti, Rakesh Ganji, Kiran Jakkala, Swetha Sankati, Kiranam Chatti, and Sharmistha Banerjee, “Mycobacterium tuberculosis Zinc Metalloprotease-1 Assists Mycobacterial Dissemination in Zebrafish,” Frontiers in Microbiology, vol. 7, 2016. View at Publisher · View at Google Scholar
  • Katsuhiko Mitachi, Shajila Siricilla, Dong Yang, Ying Kong, Karolina Skorupinska-Tudek, Ewa Swiezewska, Scott G. Franzblau, and Michio Kurosu, “Fluorescence-based assay for polyprenyl phosphate-GlcNAc-1-phosphate transferase (WecA) and identification of novel antimycobacterial WecA inhibitors,” Analytical Biochemistry, 2016. View at Publisher · View at Google Scholar
  • Yirang Na, Sang-Nae Cho, Seung Hyeok Seok, Sungmo Je, Hailian Quan, and Bum-Joon Kim, “An in vitro model of granuloma-like cell aggregates substantiates early host immune responses against Mycobacterium massiliense infection,” Biology Open, vol. 5, no. 8, pp. 1118–1127, 2016. View at Publisher · View at Google Scholar
  • Eric R. G. Lewis, and Alfredo G. Torres, “ The art of persistence—the secrets to Burkholderia chronic infections ,” Pathogens and Disease, vol. 74, no. 6, pp. ftw070, 2016. View at Publisher · View at Google Scholar
  • Collin R. Diedrich, Jennifer O'Hern, Maximiliano G. Gutierrez, Nafiesa Allie, Patricia Papier, Graeme Meintjes, Anna K. Coussens, Helen Wainwright, and Robert J. Wilkinson, “ Relationship Between HIV Coinfection, Interleukin 10 Production, and Mycobacterium tuberculosis in Human Lymph Node Granulomas ,” Journal of Infectious Diseases, pp. jiw313, 2016. View at Publisher · View at Google Scholar
  • Neha Agrawal, Chandrika Bhattacharyya, Ankur Mukherjee, Ubaid Ullah, Bhaswati Pandit, Kanury V.S. Rao, and Partha P. Majumder, “Dissecting host factors that regulate the early stages of tuberculosis infection,” Tuberculosis, 2016. View at Publisher · View at Google Scholar
  • Richard M. Armstrong, Katherine L. Adams, Joseph E. Zilisch, Daniel J. Bretl, Hiromi Sato, David M. Anderson, and Thomas C. Zahrt, “Rv2744c Is a PspA Ortholog That Regulates Lipid Droplet Homeostasis and Nonreplicating Persistence in Mycobacterium tuberculosis,” Journal Of Bacteriology, vol. 198, no. 11, pp. 1645–1661, 2016. View at Publisher · View at Google Scholar
  • Thais Barboza Bertolini, Alexandre Ignacio de Souza, Ana Flávia Gembre, Annie Rocio Piñeros, Rafael de Queiroz Prado, João Santana Silva, Leandra Naira Zambelli Ramalho, and Vânia Luiza Deperon Bonato, “ Genetic background affects the expansion of macrophage subsets in the lungs of Mycobacterium tuberculosis -infected hosts ,” Immunology, vol. 148, no. 1, pp. 102–113, 2016. View at Publisher · View at Google Scholar
  • Guanxiang Liang, Nilusha Malmuthuge, Yongjuan Guan, Yuwei Ren, Philip J. Griebel, and Le Luo Guan, “Altered microRNA expression and pre-mRNA splicing events reveal new mechanisms associated with early stage Mycobacterium avium subspecies paratuberculosis infection,” Scientific Reports, vol. 6, pp. 24964, 2016. View at Publisher · View at Google Scholar
  • Dede K.W. Man, Michael Y.T. Chow, Luca Casettari, Mercedes Gonzalez-Juarrero, and Jenny K.W. Lam, “Potential and development of inhaled RNAi therapeutics for the treatment of pulmonary tuberculosis,” Advanced Drug Delivery Reviews, 2016. View at Publisher · View at Google Scholar
  • Shubhra Srivastava, Manisha Pathak, Himanshu Pandey, Sarita Tripathi, Rajiv Garg, Shailja Misra-Bhattacharya, and Ashish Arora, “Molecular characterization of novel immunodominant molybdenum cofactor biosynthesis protein Cl (Rv3111) from Mycobacterium tuberculosis H37Rv,” Biochimica Et Biophysica Acta-General Subjects, vol. 1860, no. 4, pp. 694–707, 2016. View at Publisher · View at Google Scholar
  • C. R. Scharn, A. C. Collins, V. R. Nair, C. E. Stamm, D. K. Marciano, E. A. Graviss, and M. U. Shiloh, “Heme Oxygenase-1 Regulates Inflammation and Mycobacterial Survival in Human Macrophages during Mycobacterium tuberculosis Infection,” The Journal of Immunology, vol. 196, no. 11, pp. 4641–4649, 2016. View at Publisher · View at Google Scholar
  • Frank Wolschendorf, Alexander Speer, Frederic Wagner, Michael Niederweis, Jim Sun, Kaitlyn Schaaf, Alexandra Duverger, and Olaf Kutsch, “Protein phosphatase, Mg2+/Mn2+-dependent 1A controls the innate antiviral and antibacterial response of macrophages during HIV-1 and Mycobacterium tuberculosis infection,” Oncotarget, vol. 7, no. 13, pp. 15394–15409, 2016. View at Publisher · View at Google Scholar
  • Wenrui Hao, Larry S. Schlesinger, and Avner Friedman, “Modeling Granulomas in Response to Infection in the Lung,” Plos One, vol. 11, no. 3, 2016. View at Publisher · View at Google Scholar
  • C.R. Diedrich, J. O’Hern, and R.J. Wilkinson, “HIV-1 and the Mycobacterium tuberculosis granuloma: a systematic review and meta-analysis,” Tuberculosis, 2016. View at Publisher · View at Google Scholar
  • Saifur R. Khan, Andrew G.M. Morgan, Karim Michail, Nutan Srivastava, Randy M. Whital, Naif Aljuhani, and Arno G. Siraki, “Metabolism of Isoniazid by Neutrophil Myeloperoxidase Leads to INH-NAD+ Adduct Formation: A Comparison of the Reactivity of Isoniazid with its Known Human Metabolites,” Biochemical Pharmacology, 2016. View at Publisher · View at Google Scholar
  • L. B. Kim, V. A. Shkurupy, and A. N. Putyatina, “Dynamic Structure of Proteoglycans/Glycosaminoglycans in the Lungs of Mice with Chronic Granulomatous Inflammation,” Bulletin of Experimental Biology and Medicine, 2016. View at Publisher · View at Google Scholar
  • Bozena Dziadek, Anna Brzostek, Marcin Grzybowski, Marek Fol, Agnieszka Krupa, Jakub Kryczka, Przemyslaw Plocinski, Anna Kurdowska, and Jaroslaw Dziadek, “Mycobacterium tuberculosis AtsG (Rv0296c), GlmU (Rv1018c) and SahH (Rv3248c) Proteins Function as the Human IL-8-Binding Effectors and Contribute to P,” Plos One, vol. 11, no. 2, 2016. View at Publisher · View at Google Scholar
  • Dyan Kunthi Nugrahaeni, Suharyo Hadisaputro, Ari Suwondo, and Edi Dharmana, “The effect of alpha-mangostin in balancing the ratio of cytokines pro-and anti-inflammation-gamma (IFN-γ/il-10) and severity of the disease in mice infected with Mycobacterium tuberculosis multidrug-resistant,” Asian Journal of Pharmaceutical and Clinical Research, vol. 9, pp. 273–277, 2016. View at Publisher · View at Google Scholar
  • Anthony L. Cunningham, Nathalie Garçon, Oberdan Leo, Leonard R. Friedland, Béatrice Laupèze, Mark Doherty, Richard Strugnell, and Peter Stern, “Vaccine development: From concept to early clinical testing,” Vaccine, vol. 34, no. 52, pp. 6655–6664, 2016. View at Publisher · View at Google Scholar
  • Nancy Gupta, Babita Agrawal, and Rakesh Kumar, “Controlling inflammation: A superior way to control TB,” Immunotherapy, vol. 8, no. 10, pp. 1157–1161, 2016. View at Publisher · View at Google Scholar
  • Berdyugina, and Yershova, “Functional and metabolic features of blood phagocytes at different forms of tubercular inflammatory process of lungs,” Medical Immunology (Russia), vol. 18, no. 1, pp. 21–32, 2016. View at Publisher · View at Google Scholar
  • Jeffrey S. Schorey, and Larry S. Schlesinger, “Innate immune responses to tuberculosis,” Microbiology Spectrum, vol. 4, no. 6, 2016. View at Publisher · View at Google Scholar
  • Pei Shen, Quan Li, Jilei Ma, Maopeng Tian, Fei Hong, Xinjie Zhai, Jianrong Li, Hanju Huang, and Chunwei Shi, “IRAK-M alters the polarity of macrophages to facilitate the survival of Mycobacterium tuberculosis,” BMC Microbiology, vol. 17, no. 1, 2017. View at Publisher · View at Google Scholar
  • Gayathri Nagalingam, Carola G. Vinuesa, Warwick J. Britton, and Bernadette M. Saunders, “ Modulation of Roquin Function in Myeloid Cells Reduces Mycobacterium tuberculosis –Induced Inflammation ,” The Journal of Immunology, vol. 199, no. 5, pp. 1796–1804, 2017. View at Publisher · View at Google Scholar
  • Hayley C. Warsinske, Robert M. DiFazio, Jennifer J. Linderman, JoAnne L. Flynn, and Denise E. Kirschner, “Identifying mechanisms driving formation of granuloma-associated fibrosis during Mycobacterium tuberculosis infection,” Journal of Theoretical Biology, 2017. View at Publisher · View at Google Scholar
  • Qi Gao, Xinfang Dong, Yanping Luo, Guochao Zhang, Jinyu Shan, Qian Wang, Qi He, Lifeng Zhang, Jingqiu Wang, Bingdong Zhu, and Xingming Ma, “Construction of human MASP-2-CCP1/2SP, CCP2SP, SP plasmid DNA nanolipoplexes and the effects on tuberculosis in BCG-infected mice,” Microbial Pathogenesis, 2017. View at Publisher · View at Google Scholar
  • Gaurang Mahajan, and Shekhar C. Mande, “Using structural knowledge in the protein data bank to inform the search for potential host-microbe protein interactions in sequence space: application to Mycobacterium tuberculosis,” BMC Bioinformatics, vol. 18, no. 1, 2017. View at Publisher · View at Google Scholar
  • Bradley E. Britigan, Prabagaran Narayanasamy, and Seoung-Ryoung Choi, “Ga(III) nanoparticles inhibit growth of both Mycobacterium tuberculosis and HIV and release of interleukin-6 (IL-6) and IL-8 in coinfected macrophages,” Antimicrobial Agents and Chemotherapy, vol. 61, no. 4, 2017. View at Publisher · View at Google Scholar
  • Alyssa J. Manning, Yulia Ovechkina, Amanda McGillivray, Lindsay Flint, David M. Roberts, and Tanya Parish, “A high content microscopy assay to determine drug activity against intracellular Mycobacterium tuberculosis,” Methods, 2017. View at Publisher · View at Google Scholar
  • Vidyullatha Peddireddy, Sankara Narayana Doddam, and Niyaz Ahmed, “Mycobacterial Dormancy Systems and Host Responses in Tuberculosis,” Frontiers in Immunology, vol. 8, 2017. View at Publisher · View at Google Scholar
  • Qingwen Zhang, Jinxia Sun, Yuli Wang, Weigang He, Lixin Wang, Yuejuan Zheng, Jing Wu, Ying Zhang, and Xin Jiang, “Antimycobacterial and Anti-inflammatory Mechanisms of Baicalin via Induced Autophagy in Macrophages Infected with Mycobacterium tuberculosis,” Frontiers in Microbiology, vol. 8, 2017. View at Publisher · View at Google Scholar
  • Stefano Giovagnoli, Aurelie Schoubben, and Maurizio Ricci, “The long and winding road to inhaled TB therapy: not only the bug’s fault,” Drug Development and Industrial Pharmacy, pp. 1–17, 2017. View at Publisher · View at Google Scholar
  • Irina V. Lyadova, “Neutrophils in Tuberculosis: Heterogeneity Shapes the Way?,” Mediators of Inflammation, vol. 2017, pp. 1–11, 2017. View at Publisher · View at Google Scholar