Immune Responses to RHAMM in Patients with Acute Myeloid Leukemia after Chemotherapy and Allogeneic Stem Cell Transplantation
Figure 1
RHAMM expression before and after chemotherapy alone or allo-SCT. Patients at diagnosis had higher copy numbers when compared to healthy donors (chemotherapy group, ; allo-SCT group, ). There was no significant difference in expression of RHAMM before (white boxes) and after (grey boxes) treatment, neither for chemotherapy alone () nor for allo-SCT (), in patients at diagnosis that reached a CR after treatment. Also patients in CR that received allo-SCT showed no difference in RHAMM transcripts before (white boxes) and after (grey boxes) transplant (). However, patients that received allo-SCT had higher copy numbers when compared to those who received chemotherapy during the CR () or continuous CR (cCR, ). Medians are shown in the box plots. RHAMM: receptor for hyaluronic acid mediated motility, allo-SCT: allogeneic stem cell transplantation, CR: complete remission, P-value: probability value.
