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Clinical and Developmental Immunology
Volume 2012, Article ID 158248, 8 pages
Research Article

Feeding Bottles Usage and the Prevalence of Childhood Allergy and Asthma

1Department of Environmental and Occupational Health, College of Medicine, National Cheng Kung University, Tainan 70403, Taiwan
2Department of Occupational Safety and Health, Chang Jung Christian University, Tainan 71101, Taiwan
3Public Health Sciences, Karlstad University, 651 88 Karlstad, Sweden
4International Centre for Indoor Environment and Energy, Technical University of Denmark, 2800 Lyngby, Denmark

Received 31 July 2011; Revised 18 November 2011; Accepted 24 November 2011

Academic Editor: Kuender D Yang

Copyright © 2012 Nai-Yun Hsu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


This study aimed to examine the association between the length of use of feeding bottles or pacifiers during childhood and the prevalence of respiratory and allergic morbidities. A large-scale questionnaire survey was performed in day care centers and kindergartens (with children’s ages ranging from 2 to 7 years) in southern Taiwan, and a total of 14,862 questionnaires completed by parents were finally recruited for data analysis. Effects of using feeding bottles on children’s wheezing/asthma (adjusted OR: 1.05, 95% CI 1.00–1.09), allergic rhinitis (adjusted OR: 1.04, 95% CI 1.00–1.08), and eczema (adjusted OR: 1.07, 95% CI 1.01–1.2) were found. Moreover, significant dose-dependent relationships were further established after an adjustment for confounders was performed that included children’s ages, gender, gestational age, birth weight, length of breastfeeding, the age when first given infant formula or complementary foods, family history, parental educational levels, and smoking status, as well as the problem of indoor water damage. This study was the first to reveal the potential risk of using plastic consumer products such as feeding bottles on the reported health status of preschool children in Asian countries.