Mechanisms behind Functional Avidity Maturation in T Cells

Table 1

Studies describing differences in antigen sensitivity between naïve and primed T cells. Differences listed are in comparison to naïve T cells.

Study	Species	T-cell phenotype	Effector T cell	Memory T-cell	Mode of (re)-stimulation
Slifka and Whitton [17], 2001	Mouse	CD8	>50 fold ↑ Ag responsiveness	>50 fold ↑ Ag responsiveness	Peptide antigen
Pihlgren et al. [12], 1996	Mouse	CD8	50 fold ↑ Ag responsiveness (proliferation)	50 fold ↑ Ag responsiveness (proliferation)	In vivo or peptide-pulsed splenocytes
Curtsinger et al. [13], 1998	Mouse	CD8		↑ Ag responsiveness (e.g., proliferation)	Beads coated with MHC/peptide
Robinson et al. [10], 1993	Human	CD3		↑ Responsiveness to TCR triggering (e.g., proliferation)	Soluble anti-CD3 Ab
Sanders et al. [7], 1989	Human	CD3		↑ Responsiveness to TCR triggering (e.g., proliferation)	Soluble anti-CD3 Ab
Schwinzer et al. [11], 1994	Human	CD3		↑ Proliferation	Anti-CD3 Ab + APC
Byrne et al. [14], 1988	Human	CD4		↑ Proliferation	Anti-CD3 Ab + APC
Croft et al. [9], 1994	Mouse	CD4	↑ Proliferation	↑ Proliferation	Anti-CD3 Ab + APC lacking co-stimulation
Luqman and Bottomly [8], 1992	Mouse	CD4		↑ Proliferation	Anti-CD3 Ab + APC lacking co-stimulation