Research Article
Prediction and Identification of Potential Immunodominant Epitopes in Glycoproteins B, C, E, G, and I of Herpes Simplex Virus Type 2
Table 1
Predicted antigenicity (antigen value) of the 20 epitopes and the EIA detection results.
| Number | Predicted epitope | Surface probability | Flexibility | β-turn | Coil | Glycosylation site Asn-X-Thr/Ser | Predicted antigen value | EIA A450 value |
| (1) | gB258–75 | 5.219 | 44–82 | 69, 71 | 69, 70 | | 1.588 | | (2) | gB2466–473 | 5.685 | 465–485 | 473 | 470 | | 2.31 | | (3) | gB2468–475 | 4.185 | 465–475 | 473 | 470 | + | 1.593 | | (4) | gB2300–306 | 1.984 | 300–306 | 301 | 301–305 | | 2.057 | | (5) | gC2326–335 | 1.320 | 328–335 | 330–332 | 333–335 | + | 2.044 | | (6) | gC295–105 | 1.315 | 95–100 | 93, 98 | 100–104 | | 2.01 | | (7) | gC2161–171 | 1.948 | 161–170 | 167 | 164–170 | + | 1.736 | | (8) | gC2216–223 | 2.242 | 216–223 | 217, 222 | 219–223 | | 2.235 | | (9) | gE2514–522 | 3.446 | 514–522 | 519 | 515 | | 2.322 | | (10) | gE2471–479 | 2.02 | 471–479 | 478 | 471–47 | | 2.287 | | (11) | gE2483–491 | 2.972 | 484–495 | 488, 492 | 485, 493 | | 2.367 | | (12) | gE2385–398 | 2.701 | 385–398 | 396 | 385–394 | | 2.49 | | (13) | gG2526–539 | 2.613 | 526–537 | 535, 539 | 530, 534 | | 1.866 | | (14) | gG2286–295 | 1.215 | 289–293 | 290 | 288 | | 1.56 | | (15) | gG2572–579 | 2.767 | 569–577 | 569, 574 | 570 | | 2.807 | | (16) | gG2350–364 | 1.844 | 350–364 | 351 | 353–358 | | 2.124 | | (17) | gI2202–226 | 2.453 | 202–226 | 203, 210, 217 | 205 | + | 1.859 | | (18) | gI2236–253 | 2.143 | 236–253 | 242, 253 | 241, 244–9, 251 | | 2.081 | | (19) | gI2286–295 | 4.729 | 287–295 | 287, 293 | | | 2.764 | | (20) | gI2319–337 | 3.427 | 319–337 | 323, 326, 333 | 321, 325, 335 | | 2.042 | |
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