|
| | Aire expression negative or negligibly positive | Aire expression moderately or strongly positive |
| Systems, organs, tissues | Techniques | Cell types | Techniques | Cell types |
|
| Bone marrow | | | isH [29]
IHC [29] | Myeloblasts [29]
Lymphoblasts [29]
Megacaryocytes [29] |
|
| Lymph nodes | WB [28]
IHC [28, 29] | Lymphocytes (germinal-center) [29] | isH [29]
RT-PCR [28–30]
IHC [29, 32] | Lymphocytes (germinal-center) [32]
Lymphocytes (paracortical) [32]
Lymphocytes (medullary) [29]
DCs [29] |
|
| Spleen | NB [26, 27]
isH [32]
RT-PCR [27]
WB [28]
IHC [28, 29, 32] | Lymphocytes (red-pulp) [32]
Lymphocytes (white-pulp) [29] | isH [29]
RT-PCR [26, 28–32]
IHC [29, 32]
IF [32] | Neutrophilic granulocytes [29]
Lymphocytes (red-pulp) [29]
Lymphocytes (white-pulp) [32]
B lymphocytes [32]
T lymphocytes [32]
DCs [29]
DCs (myeloid-lineage) [28, 31]
DCs (lymphoid-lineage) [28]
Macrophages [29]
Smooth-muscle cells [29] |
|
| Fetal liver | | | RT-PCR [29] | |
|
| Adult liver | NB [26, 27]
isH [32]
RT-PCR [27, 30]
WB [28, 32]
IHC [28, 32] | | isH [29]
RT-PCR [28, 29, 32]
IHC [29, 34] | Hepatocytes [29, 34]
Küpffer cells [29] |
|
| Peripheral blood leukocytes | RT-PCR [28] | | ICC [29] | Neutrophilic granulocytes [29]
PBLs [29]
Monocytes [29] |
|
| Skeletal muscle | NB [26, 27]
WB [28]
IHC [28] | | RT-PCR [26, 28] | |
|
| Heart | NB [26]
isH [32]
RT-PCR [27, 30]
IHC [32] | | RT-PCR [26, 32] | |
|
| Respiratory system (upper and lower tract) | NB [26]
isH [32]
RT-PCR [30]
WB [28]
IHC [28, 32] | Small-airway epithelial cells [32]
Alveolar cells [32] | RT-PCR [26, 27, 32]
IHC [29, 32] | Airway epithelial cells [29]
Large-airway epithelial cells [32]
Type-1 and type-2 pneumocytes [29]
Alveolar macrophages [29] |
|
| Salivary glands | RT-PCR [30] | | IHC [29] | Tubulo-acinar and duct cells [29] |
|
| Gastrointestinal system (upper tract) | NB [27]
isH [32]
RT-PCR [30] | | RT-PCR [32]
IHC [29] | Mucosal and glandular epithelial cells [29] |
|
| Gastrointestinal system (small intestine and large bowel) | NB [27]
isH [32]
IHC [32] | Enterocytes (small intestine) [32]
Neuroendocrine cells [32] | RT-PCR [32]
IHC [29, 32] | Mucosal and glandular epithelial cells [29]
Goblet cells [32] |
|
| Hypophysis | | | IHC [29] | Anterior- and intermediate-lobe cells [29] |
|
| Thyroid | RT-PCR [27, 30] | | IHC [29] | Follicular and parafollicular cells [29] |
|
| Pancreas | RT-PCR [27, 28, 30] | | IHC [29] | Langerhans-islet cells [29]
Acinar cells [29] |
|
| Adrenal gland | isH [32]
RT-PCR [30, 32]
WB [28, 32]
IHC [28, 32] | | RT-PCR [27, 28]
IHC [29] | Cortical-layer cells [29]
Medullary chromaffin cells [29] |
|
| Urinary system | NB [26]
isH [32]
RT-PCR [26, 30]
WB [28]
IHC [28] | | isH [29]
RT-PCR [27, 29, 32]
IHC [29, 32] | Glomerular and tubular epithelial cells [29, 32]
Urinary-tract epithelial cells [29]
Bladder smooth-muscle cells [29] |
|
| Male genital system | NB [26]
isH [32]
WB [28]
IHC [28, 32] | Mature germinal cells [32] | isH [29]
RT-PCR [26–29, 32]
IHC [29, 32] | Germinal cells [29]
Immature germinal cells [32]
Sertoli cells [29]
Leydig cells [29]
Spermatic-tract epithelial cells [29] |
|
| Female genital system | isH [32]
WB [28]
IHC [28] | | isH [29]
RT-PCR [27, 30, 32]
IHC [29, 32] | Oocytes [29]
Follicular cells [29, 32]
Luteal cells [29]
Interstitial cells [29]
Fallopian-tube epithelial cells [32]
Endometrial cells [29]
Myometrial cells [29] |
|
| Central and peripheral nervous system | NB [26]
isH [32]
RT-PCR [26] | | isH [29]
RT-PCR [29, 32]
IHC [29, 32, 34] | Neurons of cerebral cortex, basal nuclei, brainstem nuclei, spinal cord [29, 32]
Granular neurons, Purkinje cells [29, 34]
Glial cells [29] |
|
| Eye and annexes | RT-PCR [30] | | IHC [29] | Retinal-layer elements [29] |
|
