Reevaluating the Concept of Treating Experimental Tumors with a Mixed Bacterial Vaccine: Coley’s Toxin

Figure 6

In vivo analysis. (a) Survival curve of Panc02 tumor-carrying C57Bl/6N mice and (b) tumor growth kinetic. After tumor establishment, mice received twice weekly i.t. or i.v. CT injections (six times in total (𝑛=3–7 mice per group). Control mice were given PBS. Mice were monitored for 28 days with adherence to ethical requirements. (c), (d) Flow cytometric phenotyping of circulating (blood) and splenic leukocyte subsets from tumor control and CT-treated animals. Values are given as mean ± SEM; ^∗𝑃<0.05 versus control; t-test. ^#𝑃<0.05 versus control; U-test.

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