Reevaluating the Concept of Treating Experimental Tumors with a Mixed Bacterial Vaccine: Coley’s Toxin

Table 2

Flow cytometric phenotyping of CT-stimulated huPBLs.

(a)  

Antigen	Donor 1				Donor 2				Donor 3				Donor 4
	0	0.05 * 10^4	0.25 * 10^4	25 * 10^5	0	0.05 * 10^4	0.25 * 10^4	25 * 10^5	0	0.05 * 10^4	0.25 * 10^4	25 * 10^5	0	0.05 * 10^4	0.25 * 10^4	25 * 10^5
	cfu/mL				cfu/mL				cfu/mL				cfu/mL
CD3^+CD4^+	35.4	34.9	38.3	45.3	26.7	24.9	24.5	37.9	40.8	41.2	31.6	49.3	43.9	31.0	35.6	51.6
CD3^+CD8^+	17.8	18.9	19.5	22.3	13.7	15.9	14.7	16.8	20.8	21.6	18.5	24.2	9.5	10.8	9.9	12.2
CD25^+	22.2	23.4	39.2	46.6	12.3	18.7	29.2	41.1	12.4	12.9	20.1	29.6	10.0	11.5	22.8	33.8
CD16^+CD56^+	14.2	17.0	14.8	17.1	30.1	23.7	23.7	22.2	11.1	9.7	10.8	9.7	12.2	10.3	11.3	10.4

Data show percentage values of huPBLs (% positive cells) following 24 hours of stimulation.

(b)  

Antigen	Donor 1				Donor 2				Donor 3				Donor 4
	0	0.05 * 10^4	0.25 * 10^4	25 * 10^5	0	0.05 * 10^4	0.25 * 10^4	25 * 10^5	0	0.05 * 10^4	0.25 * 10^4	25 * 10^5	0	0.05 * 10^4	0.25 * 10^4	25 * 10^5
	cfu/mL				cfu/mL				cfu/mL				cfu/mL
CD3^+CD4^+	33.4	38.2	42.6	52.5	16.0	16.2	22.0	33.2	31.0	33.6	31.7	53.7	35.5	35.0	33.5	61.0
CD3^+CD8^+	14.3	13.8	18.5	20.8	11.2	13.0	12.5	15.1	20.3	22.2	22.4	26.1	10.2	8.9	11.8	13.1
CD25^+	9.0	18.5	23.04	28.8	11.0	20.5	25.4	33.3	9.8	20.8	21.4	25.6	9.7	20.5	15.9	28.9
CD16^+CD56^+	8.9	8.1	8.0	8.0	16.5	27.6	14.2	14.5	5.8	8.4	6.4	6.2	7.8	2.5	6.5	7.8

Data show percentage values of huPBLs (% positive cells) following 72 hours of stimulation.