Journal of Immunology Research / 2012 / Article / Fig 2

Review Article

Current Concepts of Hyperinflammation in Chronic Granulomatous Disease

Figure 2

Other recently proposed mechanisms of hyperinflammation in CGD. Three independent mechanisms leading to hyperinflammation with increased numbers of Th17 cells have been recently proposed in CGD: Reduced IDO and Nrf2 activity and increased NLRP3 activation.

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