Association between IL17 Polymorphisms and Risk of Cervical Cancer in Chinese Women
Table 3
Association between the allele frequency and genotype distribution of rs763780 polymorphism and patient’s characteristics.
Characteristics
Total number
Genotype
P value
Allele
P value
OR (95% CI)
CC
CT
TT
C
T
Age
≤45 year
200
3 (1.5)
53 (26.5)
144 (72.0)
0.831
59 (14.8)
341 (85.2)
0.850
0.96 (0.61–1.51)
>45 year
111
1 (0.9)
32 (28.8)
78 (70.3)
34 (15.3)
188 (84.7)
Clinical stage
I
135
3 (2.2)
43 (31.9)
89 (65.9)
Ref
49 (18.1)
221 (81.9)
Ref
0.66 (0.42–1.03) 0.347 (0.04–2.72)
II
169
1 (0.6)
41 (24.3)
127 (75.1)
0.137
43 (12.7)
295 (87.3)
0.064
III
7
0 (0.0)
1 (14.3)
6 (85.7)
0.547
1 (7.1)
13 (92.9)
0.292
Tumor differentiation
Poor
251
4 (1.6)
72 (28.7)
175 (69.7)
0.312
80 (15.9)
422 (84.1)
0.159
1.56 (0.84–2.91)
Well-moderate
60
0 (0.0)
13 (21.7)
47 (78.3)
13 (10.8)
107 (89.2)
Lymph node status
Positive
55
0 (0.0)
16 (29.1)
39 (70.9)
0.626
16 (14.5)
94 (85.5)
0.895
0.96 (0.54–1.72)
Negative
256
4 (1.6)
69 (26.9)
183 (71.5)
77 (15.0)
435 (85.0)
Parametrial invasion
Positive
95
2 (2.1)
28 (29.5)
65 (68.4)
0.574
32 (16.8)
158 (83.2)
0.381
1.23 (0.77–1.96)
Negative
216
2 (0.9)
57 (26.4)
157 (72.7)
61 (14.1)
371 (85.9)
Peritumor intravascular cancer emboli
Positive
121
2 (1.7)
28 (23.1)
91 (75.2)
0.403
32 (13.2)
210 (86.8)
0.335
0.80 (0.50–1.27)
Negative
190
2 (1.1)
57 (30.0)
131 (68.9)
61 (16.1)
319 (83.9)
corresponds to the number of individuals. Adjusted by age, clinical stage, tumor differentiation, lymph node status, parametrial invasion and peritumor intravascular cancer emboli. Poor: undifferentiated cell with a spindle shape and presence of nuclear fission; moderate: individual cell keratinization but no cellular bridge or keratin pearl formation; well: differentiated cells with keratin pearl. Boldfaced values indicate a significant difference at the 5% level.
