Perinatal Gene-Gene and Gene-Environment Interactions on IgE Production and Asthma Development

Table 1

Gene-gene interactions on IgE production and asthma phenotype.

Total IgE levels/ asthma phenotype		Gene-gene interactions
Prenatal	IgE levels (cord blood, infant blood)	CD86-VTCN1 [9]
		IL13-CCL17 [10]
		IL1RL1-BPI [11]
		TGFBR2-IL2RA [12]
		IL13-CCL17-CXCL10 [10]
		MD2-ITGB2-BPI [11]
Childhood	IgE levels	CD14-AOAH [13]
		IL1RL1-NOD1 [11]
		IL13-IL4RA [14, 15]
		IL13-IL13RA1 [16]
		IL13-TARC [17]
		TLR2-TGFBR2 [12]
		MD2-MAP3KIP2-BPI [11]
		TLR2-IL6RA-IL2RA [12]
	Asthma	CD14-AOAH [13]
		CD274-LILRA4 [9]
		GSNOR-B2AR [18]
		IL4-IL4RA [19]
		IL6-IL6R [20]
		IL13-IL4R [21]
		IL13-IL4RA [15, 17, 22]
		LTA4H-ALOX5AP [23]
		SOCS1-MAP3K7IP1 [11]
		TNC-NPSR1 [24]
		EPHX1-CYP1B1-CYP2D6; [25]
		IL2RA-FOXP3-IL2RA [12]
		IRAK1-NOD1-MAPK7IP1; [11]
		STAT6-STAT4-IFNG [26]
		TLR2-IL2RA-TGFBR2 [12]
		B2AR-CCR3-CysLTR1-; FCER1B [27]
		INSIG2-IL4-CHIA-ADIPOQ-; ALOX5 [28]
		IL4-STUB1-ADRB2-IL4RA-; IL13RA2-CHIA [28]