Perinatal Gene-Gene and Gene-Environment Interactions on IgE Production and Asthma Development

Table 4

Environmental modification of epigenetic program on IgE production and asthma.

Phenotypes	Environment factors-epigenetic modification
IgE levels	High-fat (HF) intake-obesity [89] murine
	Maternal diet with methyl donors-82 loci [90] murine
	Aspergillus fumigatus-diesel exhaust particles (DEP)-IL4 promoter [91] murine
	Aspergillus fumigatus-diesel exhaust particles (DEP)-IFNG promoter [91] murine
Asthma	Folic acid supplements in pregnancy [92]
	A lwoffii F78-IFNG promoter [93] murine
	Maternal diet with methyl donors-82 loci [90] murine
	Pollution-ACSL3 [65]
	Microbial exposure-IFNG [94]