| mChr | Markers | Region (Mbp) | Locus name (mouse) | Peak marker name | Peak marker position |
Mouse gene And its position (Mbp) | References (mouse) |
Corresponding human Chr position (Mbp) | Human locus name
|
| 1 | D1Mit188– D1Mit122 | 3.9–40.5 | mCia14 | D1Mit244 | 37.6 | Aff3 | (38.2) | [9, 40, 92, 93] | 2q11 | (100.2) | AFF3 | 1 | D1Mit426– D1Mit209 | 90.4–193.3 | mCia9 Pgia1 | D1Mit166 | 178.3 | Fcgr2b | (170.9) | [57, 92, 93] | 1q23 | (172.9) | FCGR2A | | | | Pia(Chr1) | D1Mit36 | 171.1 | | | | | | | 2 | D2Mit79– D2Mit237 | 21.9–40.8 | mCia2 mCia4 | D2Mit238 | 33.9 | Traf1 /Hc | (34.8) | [2, 40–44] | 9q33 | (123.6) | TRAF1/ C5 | | | | Pgia2 HS | D2Mit81 | 33.4 | | | | | | | 3 | D3Mit75– D3Mit284 | 100.5–103.6 | mCia21 mCia22 | D2Mit75 D2Mit284 | 100.5 103.6 | Cd2 Ptpn22 | (100.5) (103.6) | [45, 46] | 1p23 1p13 | (114.3) (117.3) | CD22
PTPN22 | 3 |
D3Mit141.1–D3Mit323 | 93.0–152.4 | Pgia26
(+3 subloci) | D3Mit158 | 109.1 | Cd2 Ptpn22 | (100.5) (103.6) | [47, 47, 48, 57, 92, 93] | 1p13 1p23 | (114.3) (117.3) | CD22
PTPN22 | | | | Pia-Chr3 | D3Mit100 | 96.8 | | | | | | | 5 | D5Mit388– D5Mit256 | 33.8–63.3 | Pgia16 mCia13 | D5Mit233 | 53.0 | Rbjp | (53.9) | [9, 44, 49] | 4p15 | (25.8) | RBJP | 6 | D6Mit86– D6Mit318 | 4.4–65.1 | Pgia19 | D6Mit267 | 29.2 | Irf5 | (29.4) | [40, 50, 93] | 7q32 | (128.2) | IRF5 | 10 | D10Mit206– D10Mit130 | 13.8–65.9 | Pgia6 Pgia6b | D10Mit124 | 20.9 | Tnfaip3 Prdm1 | (18.7) (44.1) | [9, 40, 43, 92, 93] | 6q23 6q21 | (138.2) (106.5) | TNFAIP3 PRDM1 | 10 | D10Mit12– D10Mit269 | 98.9–128.4 | mCia8
(“locus 5”) AIL(Chr10)
| D10Mit102 D10Mit261 | 120.3 85.0 | Kif5a Pip4k2c | (126.7) (126.6) | [40, 50, 58, 58, 94] | 12q13 12q13 | (57.9) (57.9) | KIF5A PIP4K2C | 13 | D13Mit258– D13Mit78 | 95.6–119.6 | Pgia15 mCia19 | D13Mit51 D13Mit53 | 105.3 113.1 | Ankrd55 IL6st | (113.0) (113.2) | [9, 44, 51, 92, 93] | 5q11 5q11 | (55.4) (55.2) | ANKRD55 IL6ST | 15 | D15Mit121– D15Mit242 | 57.9–90.2 | Pgia9 | D15Mit28 | 74.4 | IL2b Bik | (78.3) (83.4) | [9, 40, 44, 62, 92, 93] | 22q12 8p3 | (37.5) (11.3) | IL2RB BIK | 15 | D15Mit279– D15Mit192 | 74.0–92.7 | mCia35–mCia37 | D15Mit159 | 87.3 | IL2b Bik | (78.3) (83.4) | [53] | 22q12 8p3 | (37.5) (11.3) | IL2RB BIK | 18 | D18Mit51– D18Mit80 | 61.3–77.0 | Pgia11 | D18Mit81 | 66.7 | Ptpn2 | (67.8) | [9, 40, 43, 93] | 18p11.3–p11.2 | (12.8) | PTPN2 |
|
|
Human RA loci validated in Caucasian, African American, and Asian ancestry and compared via meta-analysis [17, 18, 54, 55, 59–61, 63]. Human RA loci validated in Caucasian, African American, and Asian ancestry and compared via meta-analysis [17, 18, 54, 55, 59–61, 63].
|