Indirect Effects of Oral Tolerance Inhibit Pulmonary Granulomas to Schistosoma mansoni Eggs

Figure 1

Reduction of granuloma by re-exposure of orally tolerant animals to the tolerated antigen. Serum levels of (a) anti-OVA antibodies and (b) anti-SEA antibodies and (c) pulmonary granuloma area and (d–i) histological aspect of pulmonary granuloma 18 days after i.v. injection of S. mansoni eggs in nonimmunized mice (granuloma group, open bars), OVA immune controls (hatched bars), and OVA-orally tolerant (black bars). Normal mice (doted bars) were not immunized with OVA neither injected with eggs. Data represent mean ± SEM. ^∗𝑃≤0.05 tolerant versus immune ^†𝑃≤0.05 immune versus normal. nd: not detected. Original magnification of HE (d–f) and Gomori’s trichrome (g–i) photomicrographs 400X; scale bars = 25 μm.

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