Thr92Ala Polymorphism of Human Type 2 Deiodinase Gene (hD2) Affects the Development of Graves' Disease, Treatment Efficiency, and Rate of Remission

Table 2

Characteristics of patients with Graves’ disease, type 2 deiodinase polymorphism genotypes.

	D2 gene genotypes
	TT (𝑛=106)	AT (𝑛=60)	AA (𝑛=14)
Genotype frequency	0.589	0.333	0.078
Age (years)	42.9±0.99	42.2±1.16	40.9±3.10
Sex (male/female)	13/93	11/49	0/12
TV (cm^3)	33.5±2.27	27.2±2.55 *	24.6±2.35 *
fT3 (pmol/L)	15.99±1.55	11.56±1.93 *	10.7±1.85 *
fT4 (pmol/L)	48.4±3.51	41.6±3.91	40.2±1.87
TSH (mU/L)	0.04±0.007	0.04±0.01	0.02±0.007 *
Heart rate (bpm)	99.8±3.01	96.73±2.80	87.2±5.3^*,**
Blood pressure (mmHg)	133.7±2.19/77.6±1.14	128.9±2.01/77.4±1.35	130.0±2.8/78.0±5.6

* 𝑃<0.01 compared to the patients with TT genotype.
** 𝑃<0.01 compared to the patients with AT and TT genotypes.