Clinical Relevance of Autoantibodies in Patients with Autoimmune Bullous Dermatosis
Figure 1
Bullous pemphigoid and pemphigus vulgaris. (a) The clinical picture of generalized pemphigoid with tense blisters, crusts, and erythematous plaques. (b) The histological picture of BP; subepidermal blister. (c) Linear basement zone deposits of IgG in BP. (d) Circulating IgG antibodies bind to the epidermal site of SSS in a patient with BP. (e) The flaccid blister in PV. (f) The histological picture of PV with intraepidermal blister. (g) DIF analysis demonstrates binding of C3 to the intercellular cement substance (ICS) in the upper stratum Malpighii. (h) An IIF study with monkey esophagus as substrate demonstrates the presence of anti-ICS antibody with antihuman IgG conjugate.
