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Clinical and Developmental Immunology
Volume 2012, Article ID 378653, 5 pages
Review Article

Immunological HCV-Associated Thrombocytopenia: Short Review

1Second Department of Propaedeutic Surgery, Laiko Hospital, Athens University Medical School, Sakellariou 4 Street, Alimos, 17455 Athens, Greece
2Blood Transfusion Department, Areteion Hospital, Athens University Medical School, 11528 Athens, Greece

Received 27 April 2012; Revised 7 June 2012; Accepted 14 June 2012

Academic Editor: Domenico Sansonno

Copyright © 2012 Dimitrios Dimitroulis et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Infection with Hepatitis C virus (HCV) is affecting about 3% of the world's population, leading to liver damage, end-stage liver disease, and development of hepatocellular carcinoma, being thus the first indication for liver transplantation in the USA. Apart from the cirrhotic-liver-derived clinical signs and symptoms several conditions with immunological origin can also arise, such as, glomerulonephritis, pulmonary fibrosis, and thrombocytopenia. HCV-related autoimmune thrombocytopenia shows specific pathogenetic characteristics as well as symptoms and signs that differ in severity and frequency from symptoms in patients that are not HCV infected. Aim of this short paper is to estimate the epidemiological characteristics of the disease, to investigate the pathogenesis and clinical manifestation, and to propose treatment strategies according to the pertinent literature.