Human Antibodies Can Cross Guinea Pig Placenta and Bind Its Neonatal Fc Receptor: Implications for Studying Immune Prophylaxis and Therapy during Pregnancy
Figure 1
Human IgG transfer to the piglets of pregnant guinea pigs injected with a human immune globulin preparation. Two pregnant sows, numbered 4 and 7, were injected with HBIGIV on days 62 and 66 of pregnancy, respectively. Total and neutralizing human IgG, and the IgG subclasses ((a), (b), and (c), resp.) in the serum of the dams and the piglets (Pg1–5 and Pg1-2, resp.) soon after farrowing (on days 67 and 68, resp.) was quantified with commercial kits. All the piglets had human IgG in their blood stream. The concentrations for total (a) and neutralizing (b) antibody as well as for all the subtypes (c) were higher in the progeny of dam number 4, which delivered five days after the HBIGIV administration, than in that of dam number 7, which delivered two days following administration.
