Review on the Relationship between Human Polyomaviruses-Associated Tumors and Host Immune System

Figure 1

Schematic representation of the polyomaviruses genome organization. The circular double-stranded DNA genome is length about 5kb. The early region encodes the functional proteins LTAg and small T-Antigen, while the late region encodes the structural proteins VP1-3. The genome of JCV, BKV, and SV40 also encodes a small structural protein named Agno. The noncoding control region (NCCR) contains the origin of replication and regulates the replication and transcription of both the early and late genes.