Review Article
Mesangial Cell-Specific Antibodies Are Central to the Pathogenesis of Lupus Nephritis
Table 2
Glomerular targets for anti-double-stranded (ds)-DNA antibodies [
11,
12].
| Molecules that directly cross-react with anti-dsDNA antibodies | Cell type/glomerular matrix |
| Alpha-actinin | Mesangial cells | Annexin A2 | Mesangial cells, epithelial cells | Ribosomal P protein | Mesangial cells, endothelial cells | Alpha-enolase | Mesangial cells, epithelial cells | Laminin | Glomerular matrix | Fibronectin | Glomerular matrix | Collagen | Glomerular matrix | Heparan sulfate | Glomerular matrix | Hyaluronic acid | Glomerular matrix |
|
|