Journal of Immunology Research / 2012 / Article / Tab 3

Review Article

Mesangial Cell-Specific Antibodies Are Central to the Pathogenesis of Lupus Nephritis

Table 3

Nephritogenic and cross-reactive anti-dsDNA Ab properties [2629].

Non-nephritogenic anti-dsDNA AbNephritogenic anti-dsDNA AbCross-reactive anti-dsDNA Ab

ClassIgG, M and AIgG mainlyIgG mainly
Somatic mutationsNoYesYes
AffinityLow HighHigh
Cross-reactivityNoYesYes
Living cell internalizationNoYessuspected
Glomerular direct bindingNoYesYes
ProteinuriaNoYesmainly

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