Table of Contents Author Guidelines Submit a Manuscript
Clinical and Developmental Immunology
Volume 2012, Article ID 582716, 15 pages
http://dx.doi.org/10.1155/2012/582716
Clinical Study

Restoration of Innate and Adaptive Immune Responses by HCV Viral Inhibition with an Induction Approach Using Natural Interferon-Beta in Chronic Hepatitis C

1Division of Gastroenterology and Hepatology, Department of Internal Medicine, Osaka Kaisei Hospital 1-6-10 Miyahara, Yodogawa-Ku, Osaka City, Osaka 532-0003, Japan
2Division of Gastroenterology and Hepatology, Department of Internal Medicine, Osaka Prefectural General Medical Center, Osaka City, Osaka 558-858, Japan
3Laboratory of Host Defenses Institute for Advanced Medical Sciences, Hyogo College of Medicine, Nishinomiya, Hyogo 663-8501, Japan
4Department of Nuclear Medicine and PET-Center, Hyogo College of Medicine, Nishinomiya, Hyogo 663-8501, Japan

Received 23 April 2012; Revised 3 June 2012; Accepted 3 June 2012

Academic Editor: Jürg Schifferli

Copyright © 2012 Y. Kishida et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. C. W. Shepard, L. Finelli, and M. J. Alter, “Global epidemiology of hepatitis C virus infection,” Lancet Infectious Diseases, vol. 5, no. 9, pp. 558–567, 2005. View at Publisher · View at Google Scholar · View at Scopus
  2. L. B. Seeff, “Natural history of chronic hepatitis C,” Hepatology, vol. 36, no. 5, pp. S35–S46, 2002. View at Publisher · View at Google Scholar · View at Scopus
  3. European Association for the Study of the Liver, “EASL Clinical Practice Guidelines: management of hepatitis C virus infection,” Journal of Hepatology, vol. 55, no. 2, pp. 245–264, 2011. View at Publisher · View at Google Scholar
  4. M. G. Ghany, D. B. Strader, D. L. Thomas, and L. B. Seeff, “Diagnosis, management, and treatment of hepatitis C: an update,” Hepatology, vol. 49, no. 4, pp. 1335–1374, 2009. View at Publisher · View at Google Scholar · View at Scopus
  5. J. G. McHutchison, G. T. Everson, S. C. Gordon et al., “Telaprevir with peginterferon and ribavirin for chronic HCV genotype 1 infection,” New England Journal of Medicine, vol. 360, no. 18, pp. 1827–1838, 2009. View at Publisher · View at Google Scholar · View at Scopus
  6. F. Poordad, J. McCone, B. R. Bacon et al., “Boceprevir for untreated chronic HCV genotype 1 infection,” New England Journal of Medicine, vol. 364, no. 13, pp. 1195–1206, 2011. View at Publisher · View at Google Scholar · View at Scopus
  7. M. E. Major, H. Dahari, K. Mihalik et al., “Hepatitis C virus kinetics and host responses associated with disease and outcome of infection in chimpanzees,” Hepatology, vol. 39, no. 6, pp. 1709–1720, 2004. View at Publisher · View at Google Scholar · View at Scopus
  8. Z. M. Younossi, “Mechanism of Viral Evaluation and Early Treatment in Hepatitis C Implication for Therapy,” Medscape CME Gastroenterology, 2009, http://medscape.com./viewarticle/713413?src=cmep&uac=132515BN.
  9. S. K. Roberts, M. D. Weltman, D. H. G. Crawford et al., “Impact of high-dose peginterferon alfa-2A on virological response rates in patients with hepatitis C genotype 1: a randomized controlled trial,” Hepatology, vol. 50, no. 4, pp. 1045–1055, 2009. View at Publisher · View at Google Scholar · View at Scopus
  10. S. Chevaliez, C. Hézode, A. Soulier et al., “High-dose pegylated interferon-α and ribavirin in nonresponder hepatitis C patients and relationship with IL-28B genotype (SYREN Trial),” Gastroenterology, vol. 141, no. 1, pp. 119–127, 2011. View at Publisher · View at Google Scholar · View at Scopus
  11. J. M. Pawlotsky, “Treatment failure and resistance with direct-acting antiviral drugs against hepatitis C virus,” Hepatology, vol. 53, no. 5, pp. 1742–1751, 2011. View at Publisher · View at Google Scholar · View at Scopus
  12. S. Koyama, K. Ishi, C. Coban, and S. Akira, “Innate immune response to viral infection,” Cytokine, vol. 43, no. 3, pp. 336–341, 2008. View at Publisher · View at Google Scholar
  13. B. A. Le and D. F. Tough, “Links between innate and adaptive immunity via type I interferon,” Current Opinion in Immunology, vol. 14, no. 4, pp. 432–436, 2002. View at Publisher · View at Google Scholar · View at Scopus
  14. F. Weber, G. Kochs, and O. Haller, “Inverse interference: how viruses fight the interferon system,” Viral Immunology, vol. 17, no. 4, pp. 498–515, 2004. View at Google Scholar · View at Scopus
  15. A. J. Sadler and B. R. G. Williams, “Interferon-inducible antiviral effectors,” Nature Reviews Immunology, vol. 8, no. 7, pp. 559–568, 2008. View at Publisher · View at Google Scholar · View at Scopus
  16. M. J. de Veer, M. Holko, M. Frevel et al., “Functional classification of interferon-stimulated genes identified using microarrays,” Journal of Leukocyte Biology, vol. 69, no. 6, pp. 912–920, 2001. View at Google Scholar · View at Scopus
  17. D. W. Leaman, M. Chawla-Sarkar, B. Jacobs et al., “Novel growth and death related interferon-stimulated genes (ISGs) in melanoma: greater potency of IFN-β compared with IFN-α2,” Journal of Interferon and Cytokine Research, vol. 23, no. 12, pp. 745–756, 2003. View at Publisher · View at Google Scholar · View at Scopus
  18. S. Pestka, C. D. Krause, and M. R. Walter, “Interferons, interferon-like cytokines, and their receptors,” Immunological Reviews, vol. 202, pp. 8–32, 2004. View at Publisher · View at Google Scholar · View at Scopus
  19. T. S. Griffith, W. A. Chin, G. C. Jackson, D. H. Lynch, and M. Z. Kubin, “Intracellular regulation of TRAIL-induced apoptosis in human melanoma cells,” Journal of Immunology, vol. 161, no. 6, pp. 2833–2840, 1998. View at Google Scholar · View at Scopus
  20. E. C. Borden, B. Jacobs, E. Hollovary et al., “Gene regulatory and clinical effects of interferon β in patients with metastatic melanoma: a phase II trial,” Journal of Interferon and Cytokine Research, vol. 31, no. 5, pp. 433–440, 2011. View at Publisher · View at Google Scholar · View at Scopus
  21. Z. Makowska, F. H. Duong, G. J. Trincucci, D. F. Tough, and M. H. Heim, “Interferon-β and interferon-λ signaling is not affected by interferon-induced refractoriness to interferon-α in vivo,” Hepatology, vol. 53, no. 4, pp. 1154–1163, 2011. View at Google Scholar · View at Scopus
  22. T. Kanto, N. Hayashi, T. Takehara et al., “Impaired allostimulatory capacity of peripheral blood dendritic cells recovered from hepatitis C virus-infected individuals,” Journal of Immunology, vol. 162, no. 9, pp. 5584–5591, 1999. View at Google Scholar · View at Scopus
  23. S. Urbani, C. Boni, G. Missale et al., “Virus-specific CD8+ lymphocytes share the same effector-memory phenotype but exhibit functional differences in acute hepatitis B and C,” Journal of Virology, vol. 76, no. 24, pp. 12423–12434, 2002. View at Publisher · View at Google Scholar · View at Scopus
  24. S. J. Polyak, K. S. A. Khabar, M. Rezeiq, and D. R. Gretch, “Elevated levels of interleukin-8 in serum are associated with hepatitis C virus infection and resistance to interferon therapy,” Journal of Virology, vol. 75, no. 13, pp. 6209–6211, 2001. View at Publisher · View at Google Scholar · View at Scopus
  25. Y. Kishida, Y. Haruna, M. Naitoh, K. Katayama, and T. Kashiwagi, “Multiple cytokine profiling of the therapeutic responses to ribavirin and pegylated interferon-2b using an “induction” approach with natural interferon- in difficult-to-treat chronic hepatitis C,” Journal of Interferon and Cytokine Research, vol. 29, no. 6, pp. 353–368, 2009. View at Publisher · View at Google Scholar · View at Scopus
  26. K. Ishak, A. Baptista, L. Bianchi et al., “Histological grading and staging of chronic hepatitis,” Journal of Hepatology, vol. 22, no. 6, pp. 696–699, 1995. View at Publisher · View at Google Scholar · View at Scopus
  27. G. Mayer, “Cytokines and immunoregulation,” in Microbiology and Immunology on-Line, R. Hunt, Ed., part one: Immunology, chapter 13, University of South Carolina School of Medicine, 2010, http://pathmicro.med.sc.edu/bowers/imm-reg-ver2.htm. View at Google Scholar
  28. H. Wright, P. Alex, T. Nguyen et al., “Multiple cytokine profiling of initial therapeutic respons in patients with chronic hepatitis C virus infection,” Digestive Diseases and Sciences, vol. 50, no. 10, pp. 1793–1803, 2005. View at Google Scholar
  29. H. Barth, J. Rybczynska, R. Patient et al., “Both innate and adaptive immunity mediate protective imunity against hepatitis C virus infection in chimpanzees,” Hepatology, vol. 54, no. 4, pp. 1135–1148, 2011. View at Publisher · View at Google Scholar
  30. B. Rehermann, “Hepatitis C virus versus innate and adaptive immune responses: a tale of coevolution and coexistence,” Journal of Clinical Investigation, vol. 119, no. 7, pp. 1745–1754, 2009. View at Publisher · View at Google Scholar · View at Scopus
  31. G. Szabo and A. Dolganiuc, “Hepatitis C and innate immunity: recent advances,” Clinics in Liver Disease, vol. 12, no. 3, pp. 675–692, 2008. View at Publisher · View at Google Scholar · View at Scopus
  32. C. B. Bigger, B. Guerra, K. M. Brasky et al., “Intrahepatic gene expression during chronic hepatitis C virus infection in chimpanzees,” Journal of Virology, vol. 78, no. 24, pp. 13779–13792, 2004. View at Publisher · View at Google Scholar · View at Scopus
  33. K. Li, N. L. Li, D. Wei, S. R. Pfeffer, M. Fan, and L. M. Pfeffer, “Activation of chemokine and inflammatory cytokine response in hepatitis C virus-infected hepatocytes depends on toll-like receptor 3 sensing of hepatitis C virus double-stranded RNA intermediates,” Hepatology, vol. 55, no. 3, pp. 666–675, 2012. View at Publisher · View at Google Scholar · View at Scopus
  34. I. G. Rodrigue-Gervaris, L. Jouan, G. Beaule et al., “Poly (I:C) and lipopolysaccharide innate sensing functions of circulating human myeloid dendritic cells are affected in vivo in hepatitis C virus-infected patients,” Journal of Virology, vol. 81, no. 11, pp. 5537–5546, 2007. View at Publisher · View at Google Scholar
  35. S. Auffermann-Gretzinger, E. B. Keeffe, and S. Levy, “Impaired dendritic cell maturation in patients with chronic, but not resolved, hepatitis C virus infection,” Blood, vol. 97, no. 10, pp. 3171–3176, 2001. View at Publisher · View at Google Scholar · View at Scopus
  36. A. Dolganiuc, K. Kodys, A. Kopasz et al., “Hepatitis C virus core and nonstructural protein 3 proteins induce pro- and anti-inflammatory cytokines and inhibit dendritic cell differentiation,” Journal of Immunology, vol. 170, no. 11, pp. 5615–5624, 2003. View at Google Scholar · View at Scopus
  37. A. L. Eisen-Vandervelde, S. N. Waggoner, Z. Q. Yao, E. M. Cale, C. S. Hahn, and Y. S. Hahn, “Hepatitis C virus core selectively suppresses interleukin-12 synthesis in human macrophages by interfering with AP-1 activation,” Journal of Biological Chemistry, vol. 279, no. 42, pp. 43479–43486, 2004. View at Publisher · View at Google Scholar · View at Scopus
  38. T. Mueller, A. Mas-Marques, C. Sarrazin et al., “Influence of interleukin 12B (IL12B) polymorphisms on spontaneous and treatment-induced recovery from hepatitis C virus infection,” Journal of Hepatology, vol. 41, no. 4, pp. 652–658, 2004. View at Publisher · View at Google Scholar · View at Scopus
  39. E. Vivier, D. H. Raulet, A. Moretta et al., “Innate or adaptive immunity? The example of natural killer cells,” Science, vol. 331, no. 6013, pp. 44–49, 2011. View at Publisher · View at Google Scholar · View at Scopus
  40. N. díaz-Valdés, L. Manterola, V. Belsúe et al., “Improved dendritic cell-based immunization against hepatitis C virus using peptide inhibitors of interleukin 10,” Hepatology, vol. 53, no. 1, pp. 23–31, 2011. View at Publisher · View at Google Scholar · View at Scopus
  41. D. Accapezzato, V. Francavilla, M. Paroli et al., “Hepatic expansion of a virus-specific regulatory CD8+ T cell population in chronic hepatitis C virus infection,” The Journal of Clinical Investigation, vol. 113, pp. 963–972, 2004. View at Google Scholar
  42. D. E. Kaplan, F. Ikeda, Y. Li et al., “Peripheral virus-specific T-cell interleukin-10 responses develop early in acute hepatitis C infection and become dominant in chronic hepatitis,” Journal of Hepatology, vol. 48, no. 6, pp. 903–913, 2008. View at Publisher · View at Google Scholar · View at Scopus
  43. G. Piazzolla, C. Tortorella, O. Schiraldi, and S. Antonaci, “Relationship between interferon-γ, interleukin-10, and interleukin-12 production in chronic hepatitis C and in vitro effects of interferon-α,” Journal of Clinical Immunology, vol. 20, no. 1, pp. 54–61, 2000. View at Publisher · View at Google Scholar · View at Scopus
  44. S. J. Polyak, K. S. A. Khabar, M. Rezeiq, and D. R. Gretch, “Elevated levels of interleukin-8 in serum are associated with hepatitis C virus infection and resistance to interferon therapy,” Journal of Virology, vol. 75, no. 13, pp. 6209–6211, 2001. View at Publisher · View at Google Scholar · View at Scopus
  45. S. J. Polyak, K. S. A. Khabar, D. M. Paschal et al., “Hepatitis C virus nonstructural 5A protein induces interleukin-8, leading to partial inhibition of the interferon-induced antiviral response,” Journal of Virology, vol. 75, no. 13, pp. 6095–6106, 2001. View at Publisher · View at Google Scholar · View at Scopus
  46. G. Askarieh, A. Alsiö, P. Pugnale et al., “Systemic and intrahepatic interferon-gamma-inducible protein 10 kDa predicts the first-phase decline in hepatitis C virus RNA and overall viral response to therapy in chronic hepatitis C,” Hepatology, vol. 51, no. 5, pp. 1523–1530, 2010. View at Google Scholar · View at Scopus
  47. M. Lagging, A. I. Romero, J. Westin et al., “IP-10 predicts viral response and therapeutic outcome in difficult-to-treat patients with HCV genotype 1 infection,” Hepatology, vol. 44, no. 6, pp. 1617–1625, 2006. View at Publisher · View at Google Scholar · View at Scopus
  48. S. Beinhardt, J. H. Aberle, M. Strasser et al., “Serum level of IP-10 increases predictive value of IL 28B polymorphisms for spontaneous clearance of acute HCV infection,” Gastroenterology, vol. 142, pp. 78–85, 2012. View at Google Scholar
  49. X. Salcedo, J. Medina, P. Sanz-Cameno et al., “The potential of angiogenesis soluble markers in chronic hepatitis C,” Hepatology, vol. 42, no. 3, pp. 696–701, 2005. View at Publisher · View at Google Scholar · View at Scopus
  50. A. Vargas, J. Berenguer, P. Catalán et al., “Association between plasma levels of eotaxin (CCL-11) and treatment response to interferon-alpha and ribavirin in HIV/HCV co-infected patients,” The Journal of Antimicrobial Chemotherapy, vol. 65, no. 2, pp. 303–306, 2010. View at Publisher · View at Google Scholar · View at Scopus
  51. C. E. Harvey, J. J. Post, P. Palladinetti et al., “Expression of the chemokine IP-10 (CXCL10) by hepatocytes in chronic hepatitis C virus infection correlates with histological severity and lobular inflammation,” Journal of Leukocyte Biology, vol. 74, no. 3, pp. 360–369, 2003. View at Publisher · View at Google Scholar · View at Scopus