Review Article
Clinical and Pathological Roles of Ro/SSA Autoantibody System
Table 1
Clinical manifestations related to anti-Ro antibodies.
| Clinical manifestation | Disease | Ro52 specificity | Reference |
| Cutaneous manifestation | | | | Photosensitivity | SLE | | [17] | RA | | [18] | Subacute cutaneous lesion | SLE/SCLE | | [19, 20] | Purpura | SLE | | [21, 22] | SS | | [23, 24] | RA | | [18] | Cutaneous NLE | NLE | | [25] |
| Sicca symptom | SS | | [26] | SSc | | [27] | RA | | [18, 28, 29] |
| Scleritis | RA | | [28] |
| Interstitial lung disease | SLE | + | [16, 30, 31] | SSc | | [32, 33] | PM/DM | | [34, 35] |
| Congenital heart disease | | | | Complete heart block | NLE | | [25, 36–38] | Prolonged QT interval | NLE | | [25] |
| Liver dysfunction | | | | Liver function test abnormality | NLE | | [25] | High serum bilirubin level | PBC | + | [39] | Advanced histological stage | PBC | + | [39] | AIH-1 | + | [40] |
| Musculoskeletal involvement | | | | Myositis | PM/DM | + | [15, 41, 42] | Arthritis | SLE | | [43] |
| Hematological disorder | | | | Leukopenia | SS | | [23] | RA | | [18] | Lymphopenia | SS | | [23] | Neutropenia | SLE | | [44] | NLE | | [25] | Anemia | NLE | | [25] | RA | | [29] | Thrombocytopenia | NLE | | [25] |
| Immunological disorder | | | | Hypocomplementemia | RA | | [18] | High serum IgG level | SS | | [23] | RA | | [28] | High serum IgM level | PBC | + | [39] |
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SLE: systemic lupus erythematosus; RA: rheumatoid arthritis; SCLE: subacute cutaneous lupus erythematosus; SS: Sjögren’s syndrome; NLE: neonatal lupus erythematosus; SSc: systemic sclerosis; PM: polymyositis; DM: dermatomyositis; PBC: primary biliary cirrhosis; AIH-1: type 1 autoimmune hepatitis.
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